Electrochemical studies of nevirapine, an anti-HIV drug, and its assay in tablets and biological samples

The electrochemical oxidation of nevirapine, an anti-HIV drug, at a glassy carbon electrode has been studied by voltammetric techniques. Nevirapine showed one well defined irreversible oxidation peak with a potential of 0.749 V in phosphate buffer at pH 10. The effects of different electrolytes, pH...

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Bibliographic Details
Published in:Journal of Electrochemical Science and Engineering 2012-06, Vol.2 (2), p.67-75
Main Authors: TERADAL, NAGAPA LAXMAN, PRASHANTH, SHANKAR NARAYAN, SEETHARAMAPPA, JALDAPPAGARI
Format: Article
Language:English
Subjects:
Nevirapine
Non-nucleoside inhibitor
Pharmaceutical formulations
Voltammetric investigations
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Summary:The electrochemical oxidation of nevirapine, an anti-HIV drug, at a glassy carbon electrode has been studied by voltammetric techniques. Nevirapine showed one well defined irreversible oxidation peak with a potential of 0.749 V in phosphate buffer at pH 10. The effects of different electrolytes, pH and scan rate on the electrochemical behaviour of nevira¬pine were examined to determine the optimum reaction conditions. The oxidation peak current was found to vary linearly with the concentration of nevirapine in the range of 5.0 – 350 µM. The limit of detection and limit of quantification values were calculated and found to be 1.026 µM and 3.420 µM, respectively. The low relative standard deviation values of inter-day and intra-day assays highlighted the good reproducibility of the proposed m¬ethod for assay of nevirapine. Further, a sensitive and accurate differential pulse voltammetric method was developed for the determination of nevirapine concentrations in pharma¬ceutical formulations.
ISSN:1847-9286
1847-9286
DOI:10.5599/jese.2012.0008