Dysgerminoma of the Left Ovary in a Patient with Balanced Translocation 46X, t(X:1) (q22;q21): A Case Report

We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and...

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Bibliographic Details
Published in:International medical case reports journal 2023-01, Vol.16, p.117-122
Main Authors: Nagata, Koh, Shimada, Takako, Eishi, Chiaki, Nishi, Masaki, Murakami, Toru, Ohashi, Kazuaki, Kajimura, Itsuki, Miura, Kiyonori
Format: Article
Language:English
Subjects:
Amenorrhea
Antigens
balanced translocation
Case Report
Case reports
Chemotherapy
Dehydrogenases
dysgerminoma
Fallopian tubes
Females
Genetic disorders
Health aspects
Hormone replacement therapy
Hormone therapy
Literature reviews
Lymphatic system
Magnetic resonance imaging
Metastasis
Mutation
Oophorectomy
Ovaries
Patients
primary amenorrhea
Tumors
Uterus
Women
X chromosomes
Y chromosomes
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Summary:We report a case of dysgerminoma in a 22-year-old woman diagnosed with chromosomal abnormality, balanced translocation 46X,t(X:1)(q22;q21). She had received hormone replacement therapy for 7 years for primary amenorrhea. She visited a primary care physician because of lower abdominal distension, and a large tumor in the pelvis was discovered. She was admitted to our hospital for further examination of the pelvic tumor. She underwent laparotomy and was diagnosed with stage IIIA1 dysgerminoma (pT3apN0pM0) of the left ovary. Young female patients without the Y chromosome who are treated for primary amenorrhea may also develop malignant germ cell tumors; therefore, gynecologists should provide hormone replacement therapy and periodic pelvic evaluation.
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S395511