Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability,...

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Bibliographic Details
Published in:Gels 2023-05, Vol.9 (5), p.431
Main Authors: Lyu, Yihan, Liu, Yusheng, He, Houzhe, Wang, Hongmei
Format: Article
Language:English
Subjects:
Biocompatibility
Biological products
Biological properties
Biomedical materials
bone
Cartilage
Chemical bonds
Cornea
Degumming
Electric fields
Enzymes
Free radicals
hydrogel
Hydrogels
Mechanical properties
Methods
Physical properties
Polymers
Raw materials
Regeneration (physiology)
Review
scaffolds
Silk
Silk fibroin
Skin
Tissue engineering
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Summary:Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability, low immunogenicity, and tunability, making it a versatile material widely applied in biological fields, particularly in tissue engineering. In tissue engineering, SF is often fabricated into hydrogel form, with the advantages of added materials. SF hydrogels have mostly been studied for their use in tissue regeneration by enhancing cell activity at the tissue defect site or counteracting tissue-damage-related factors. This review focuses on SF hydrogels, firstly summarizing the fabrication and properties of SF and SF hydrogels and then detailing the regenerative effects of SF hydrogels as scaffolds in cartilage, bone, skin, cornea, teeth, and eardrum in recent years.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9050431