Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory fa...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2024-05, Vol.18, p.1362494-1362494
Main Authors: Gao, Yating, Wang, Yu, Wu, Yaqi, Liu, Shengwen
Format: Article
Language:English
Subjects:
biomaterial scaffolds
Biomedical materials
cell transplantation
Cellular Neuroscience
Cytokines
Fibroblasts
Inflammation
Injuries
Ischemia
Kinases
Neutrophils
Proteins
Scars
Spinal cord
spinal cord injury
spinal cord repair
stem cell
Tumor necrosis factor-TNF
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Summary:Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2024.1362494