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Thermoresponsive Dual-Structured Gel Emulsions Stabilized by Glycyrrhizic Acid Nanofibrils in Combination with Monoglyceride Crystals
Responsive dual-structured emulsions and gel emulsions have attracted more and more attention due to their complex microstructures, on-demand responsive properties, and controlled release of active cargoes. In this work, the effect of monoglyceride (MG)-based oil phase structuring on the formation a...
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Published in: | Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (19), p.6542 |
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description | Responsive dual-structured emulsions and gel emulsions have attracted more and more attention due to their complex microstructures, on-demand responsive properties, and controlled release of active cargoes. In this work, the effect of monoglyceride (MG)-based oil phase structuring on the formation and stability, structural properties, and thermoresponsive and cargo release behavior of gel emulsions stabilized by glycyrrhizic acid (GA) nanofibrils were investigated. Owing to the formation of GA fibrillar networks in the aqueous phase and MG crystalline networks in the oil phase, a stable dual-structured gel emulsion can be successfully developed. The microstructure of the dual-structured gel emulsions largely depended on the concentration of MG in the oil phase. At low MG concentrations (1–2 wt%), the larger formed and lamellar MG crystals may pierce the interfacial fibrillar film, inducing the formation of partially coalesced droplets. In contrast, at high MG concentrations (4 wt% or above), the smaller MG crystals with enhanced interfacial activity can lead to the formation of a bilayer shell of GA nanofibrils and MG crystals, thus efficiently inhibiting the interfacial film damage and forming a jamming structure with homogeneously distributed small droplets. Compared to pure GA nanofibril gel emulsions, the GA−MG dual-structured gel emulsions showed significantly improved mechanical performance as well as good thermoresponsive behavior. Moreover, these stable GA−MG gel emulsions can be used as food-grade delivery vehicles for encapsulating and protecting hydrophobic and hydrophilic bioactive cargoes. They also have great potential as novel and efficient aroma delivery systems showing highly controlled volatile release. The dual-structured emulsion strategy is expected to broaden the applications of natural saponin GA-based gel emulsions in the food, pharmaceutical, and personal care industries. |
doi_str_mv | 10.3390/molecules27196542 |
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In this work, the effect of monoglyceride (MG)-based oil phase structuring on the formation and stability, structural properties, and thermoresponsive and cargo release behavior of gel emulsions stabilized by glycyrrhizic acid (GA) nanofibrils were investigated. Owing to the formation of GA fibrillar networks in the aqueous phase and MG crystalline networks in the oil phase, a stable dual-structured gel emulsion can be successfully developed. The microstructure of the dual-structured gel emulsions largely depended on the concentration of MG in the oil phase. At low MG concentrations (1–2 wt%), the larger formed and lamellar MG crystals may pierce the interfacial fibrillar film, inducing the formation of partially coalesced droplets. In contrast, at high MG concentrations (4 wt% or above), the smaller MG crystals with enhanced interfacial activity can lead to the formation of a bilayer shell of GA nanofibrils and MG crystals, thus efficiently inhibiting the interfacial film damage and forming a jamming structure with homogeneously distributed small droplets. Compared to pure GA nanofibril gel emulsions, the GA−MG dual-structured gel emulsions showed significantly improved mechanical performance as well as good thermoresponsive behavior. Moreover, these stable GA−MG gel emulsions can be used as food-grade delivery vehicles for encapsulating and protecting hydrophobic and hydrophilic bioactive cargoes. They also have great potential as novel and efficient aroma delivery systems showing highly controlled volatile release. The dual-structured emulsion strategy is expected to broaden the applications of natural saponin GA-based gel emulsions in the food, pharmaceutical, and personal care industries.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules27196542</identifier><identifier>PMID: 36235079</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Aroma ; Bilayers ; Chemical properties ; Controlled release ; Cosmetics ; Crystal structure ; Crystals ; Droplets ; dual-structured gel emulsions ; Emulsions ; Food ; glycyrrhizic acid ; Hydrogels ; Hydrophobicity ; Jamming ; Materials ; Materials research ; Mechanical properties ; Microscopy ; Microstructure ; monoglyceride ; Monoglycerides ; Nanotechnology ; Oil ; Saponins ; Structural stability ; Thermal properties ; thermoresponsive</subject><ispartof>Molecules (Basel, Switzerland), 2022-10, Vol.27 (19), p.6542</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-dfc8f205cf89de8349cc0854a3cb4179afe00963736357866cf2ad07e8f774c83</citedby><cites>FETCH-LOGICAL-c509t-dfc8f205cf89de8349cc0854a3cb4179afe00963736357866cf2ad07e8f774c83</cites><orcidid>0000-0002-5865-4301</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2724276259/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2724276259?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><creatorcontrib>Chen, Jialing</creatorcontrib><creatorcontrib>Li, Qing</creatorcontrib><creatorcontrib>Du, Ruijie</creatorcontrib><creatorcontrib>Yu, Xinke</creatorcontrib><creatorcontrib>Wan, Zhili</creatorcontrib><creatorcontrib>Yang, Xiaoquan</creatorcontrib><title>Thermoresponsive Dual-Structured Gel Emulsions Stabilized by Glycyrrhizic Acid Nanofibrils in Combination with Monoglyceride Crystals</title><title>Molecules (Basel, Switzerland)</title><description>Responsive dual-structured emulsions and gel emulsions have attracted more and more attention due to their complex microstructures, on-demand responsive properties, and controlled release of active cargoes. In this work, the effect of monoglyceride (MG)-based oil phase structuring on the formation and stability, structural properties, and thermoresponsive and cargo release behavior of gel emulsions stabilized by glycyrrhizic acid (GA) nanofibrils were investigated. Owing to the formation of GA fibrillar networks in the aqueous phase and MG crystalline networks in the oil phase, a stable dual-structured gel emulsion can be successfully developed. The microstructure of the dual-structured gel emulsions largely depended on the concentration of MG in the oil phase. At low MG concentrations (1–2 wt%), the larger formed and lamellar MG crystals may pierce the interfacial fibrillar film, inducing the formation of partially coalesced droplets. In contrast, at high MG concentrations (4 wt% or above), the smaller MG crystals with enhanced interfacial activity can lead to the formation of a bilayer shell of GA nanofibrils and MG crystals, thus efficiently inhibiting the interfacial film damage and forming a jamming structure with homogeneously distributed small droplets. Compared to pure GA nanofibril gel emulsions, the GA−MG dual-structured gel emulsions showed significantly improved mechanical performance as well as good thermoresponsive behavior. Moreover, these stable GA−MG gel emulsions can be used as food-grade delivery vehicles for encapsulating and protecting hydrophobic and hydrophilic bioactive cargoes. They also have great potential as novel and efficient aroma delivery systems showing highly controlled volatile release. The dual-structured emulsion strategy is expected to broaden the applications of natural saponin GA-based gel emulsions in the food, pharmaceutical, and personal care industries.</description><subject>Aroma</subject><subject>Bilayers</subject><subject>Chemical properties</subject><subject>Controlled release</subject><subject>Cosmetics</subject><subject>Crystal structure</subject><subject>Crystals</subject><subject>Droplets</subject><subject>dual-structured gel emulsions</subject><subject>Emulsions</subject><subject>Food</subject><subject>glycyrrhizic acid</subject><subject>Hydrogels</subject><subject>Hydrophobicity</subject><subject>Jamming</subject><subject>Materials</subject><subject>Materials research</subject><subject>Mechanical properties</subject><subject>Microscopy</subject><subject>Microstructure</subject><subject>monoglyceride</subject><subject>Monoglycerides</subject><subject>Nanotechnology</subject><subject>Oil</subject><subject>Saponins</subject><subject>Structural stability</subject><subject>Thermal properties</subject><subject>thermoresponsive</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplkk1v1DAQhiMEoqXwA7hZ4sJlW8cfcXxBWi1lqVTg0HK2HGe865VjL3ZSlN7533jZqqIgH8aaed9n_DFV9bbG55RKfDFED2bykImoZcMZeVad1ozgBcVMPv9rf1K9ynmHMalZzV9WJ7QhlGMhT6tft1tIQ0yQ9zFkdwfo46T94mZMkxmnBD1ag0eXw-SzKwJ0M-rOeXdfCt2M1n42c0pbd-8MWhrXo686ROu65HxGLqBVHDoX9Fi86Kcbt-hLDHFTXJBcD2iV5jxqn19XL2wJ8OYhnlXfP13erj4vrr-tr1bL64XhWI6L3prWEsyNbWUPLWXSGNxypqnpWC2ktoCxbKigDeWibRpjie6xgNYKwUxLz6qrI7ePeqf2yQ06zSpqp_4kYtoonUZnPCjGNRcSi0KWDHe8M7rThJgOayGh5oX14cjaT90AvYEwJu2fQJ9WgtuqTbxTkguK66YA3j8AUvwxQR7V4LIB73WAOGVFBOHlWynBRfruH-kuTimUpzqoGBEN4bKozo-qjS4XcMHG0teU1cPgTAxgXckvBeOFitsDtj4aTIo5J7CPp6-xOkyY-m_C6G89qMfr</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Chen, Jialing</creator><creator>Li, Qing</creator><creator>Du, Ruijie</creator><creator>Yu, Xinke</creator><creator>Wan, Zhili</creator><creator>Yang, Xiaoquan</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5865-4301</orcidid></search><sort><creationdate>20221001</creationdate><title>Thermoresponsive Dual-Structured Gel Emulsions Stabilized by Glycyrrhizic Acid Nanofibrils in Combination with Monoglyceride Crystals</title><author>Chen, Jialing ; Li, Qing ; Du, Ruijie ; Yu, Xinke ; Wan, Zhili ; Yang, Xiaoquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-dfc8f205cf89de8349cc0854a3cb4179afe00963736357866cf2ad07e8f774c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aroma</topic><topic>Bilayers</topic><topic>Chemical properties</topic><topic>Controlled release</topic><topic>Cosmetics</topic><topic>Crystal structure</topic><topic>Crystals</topic><topic>Droplets</topic><topic>dual-structured gel emulsions</topic><topic>Emulsions</topic><topic>Food</topic><topic>glycyrrhizic acid</topic><topic>Hydrogels</topic><topic>Hydrophobicity</topic><topic>Jamming</topic><topic>Materials</topic><topic>Materials research</topic><topic>Mechanical properties</topic><topic>Microscopy</topic><topic>Microstructure</topic><topic>monoglyceride</topic><topic>Monoglycerides</topic><topic>Nanotechnology</topic><topic>Oil</topic><topic>Saponins</topic><topic>Structural stability</topic><topic>Thermal properties</topic><topic>thermoresponsive</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jialing</creatorcontrib><creatorcontrib>Li, Qing</creatorcontrib><creatorcontrib>Du, Ruijie</creatorcontrib><creatorcontrib>Yu, Xinke</creatorcontrib><creatorcontrib>Wan, Zhili</creatorcontrib><creatorcontrib>Yang, Xiaoquan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jialing</au><au>Li, Qing</au><au>Du, Ruijie</au><au>Yu, Xinke</au><au>Wan, Zhili</au><au>Yang, Xiaoquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermoresponsive Dual-Structured Gel Emulsions Stabilized by Glycyrrhizic Acid Nanofibrils in Combination with Monoglyceride Crystals</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><date>2022-10-01</date><risdate>2022</risdate><volume>27</volume><issue>19</issue><spage>6542</spage><pages>6542-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Responsive dual-structured emulsions and gel emulsions have attracted more and more attention due to their complex microstructures, on-demand responsive properties, and controlled release of active cargoes. In this work, the effect of monoglyceride (MG)-based oil phase structuring on the formation and stability, structural properties, and thermoresponsive and cargo release behavior of gel emulsions stabilized by glycyrrhizic acid (GA) nanofibrils were investigated. Owing to the formation of GA fibrillar networks in the aqueous phase and MG crystalline networks in the oil phase, a stable dual-structured gel emulsion can be successfully developed. The microstructure of the dual-structured gel emulsions largely depended on the concentration of MG in the oil phase. At low MG concentrations (1–2 wt%), the larger formed and lamellar MG crystals may pierce the interfacial fibrillar film, inducing the formation of partially coalesced droplets. In contrast, at high MG concentrations (4 wt% or above), the smaller MG crystals with enhanced interfacial activity can lead to the formation of a bilayer shell of GA nanofibrils and MG crystals, thus efficiently inhibiting the interfacial film damage and forming a jamming structure with homogeneously distributed small droplets. Compared to pure GA nanofibril gel emulsions, the GA−MG dual-structured gel emulsions showed significantly improved mechanical performance as well as good thermoresponsive behavior. Moreover, these stable GA−MG gel emulsions can be used as food-grade delivery vehicles for encapsulating and protecting hydrophobic and hydrophilic bioactive cargoes. They also have great potential as novel and efficient aroma delivery systems showing highly controlled volatile release. The dual-structured emulsion strategy is expected to broaden the applications of natural saponin GA-based gel emulsions in the food, pharmaceutical, and personal care industries.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36235079</pmid><doi>10.3390/molecules27196542</doi><orcidid>https://orcid.org/0000-0002-5865-4301</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aroma Bilayers Chemical properties Controlled release Cosmetics Crystal structure Crystals Droplets dual-structured gel emulsions Emulsions Food glycyrrhizic acid Hydrogels Hydrophobicity Jamming Materials Materials research Mechanical properties Microscopy Microstructure monoglyceride Monoglycerides Nanotechnology Oil Saponins Structural stability Thermal properties thermoresponsive |
title | Thermoresponsive Dual-Structured Gel Emulsions Stabilized by Glycyrrhizic Acid Nanofibrils in Combination with Monoglyceride Crystals |
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