Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution

Periodontitis represents a complex inflammatory disease that compromises the integrity of the tooth-supporting tissue through the interaction of specific periodontal pathogens and the host's immune system. Experimental data help to outline the idea that the molecular way towards periodontitis i...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4338
Main Authors: Greabu, Maria, Giampieri, Francesca, Imre, Marina Melescanu, Mohora, Maria, Totan, Alexandra, Pituru, Silviu Mirel, Ionescu, Ecaterina
Format: Article
Language:English
Subjects:
Autophagy
Disease Progression
Humans
oxidative stress
periodontitis
Periodontitis - metabolism
Periodontitis - microbiology
Periodontitis - pathology
Periodontitis - therapy
Reactive Oxygen Species - metabolism
Review
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Summary:Periodontitis represents a complex inflammatory disease that compromises the integrity of the tooth-supporting tissue through the interaction of specific periodontal pathogens and the host's immune system. Experimental data help to outline the idea that the molecular way towards periodontitis initiation and progression presents four key steps: bacterial infection, inflammation, oxidative stress, and autophagy. The aim of this review is to outline the autophagy involvement in the pathogenesis and evolution of periodontitis from at least three points of view: periodontal pathogen invasion control, innate immune signaling pathways regulation and apoptosis inhibition in periodontal cells. The exact roles played by reactive oxygen species (ROS) inside the molecular mechanisms for autophagy initiation in periodontitis still require further investigation. However, clarifying the role and the mechanism of redox regulation of autophagy in the periodontitis context may be particularly beneficial for the elaboration of new therapeutic strategies.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25184338