Prevalence and antimicrobial susceptibility of respiratory pathogens in patients with cystic fibrosis

Respiratory infection is very common in patients suffering from cystic fibrosis (CF). However, the antimicrobial resistance rate of isolates from CF patients is not often documented. In this study, 279 respiratory specimens of 146 patients were prospectively collected from July to December 2006. Mic...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2010-08, Vol.14 (4), p.406-409
Main Authors: Paixão, Vilma Almeida, Barros, Tânia Fraga, Mota, Clélia Maria C, Moreira, Tamy Fagundes, Santana, Maria Angélica, Reis, Joice Neves
Format: Article
Language:English
Subjects:
antimicrobial resistance
cystic fibrosis
INFECTIOUS DISEASES
Pseudomonas aeruginosa
Staphylococcus aureus
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Summary:Respiratory infection is very common in patients suffering from cystic fibrosis (CF). However, the antimicrobial resistance rate of isolates from CF patients is not often documented. In this study, 279 respiratory specimens of 146 patients were prospectively collected from July to December 2006. Microbiological cultures and antimicrobial susceptibility tests of the most frequently isolated bacteria were performed. Sputum and oropharyngeal swabs were processed for culture. During the study period, 50% of the patients harbored Staphylococcus aureus, 35% Pseudomonas aeruginosa, 4.7% Haemophilus influenzae. Methicillin resistant S. aureus (MRSA) were detected in 8 (6%) patients; ESBL and MBL-producing P. aeruginosa were not identified in these patients. The detection of MRSA in CF patients confirms that antimicrobial resistance patterns should be always kept under surveillance. Moreover, hygiene regulations in CF clinics should prevent a further spread of resistant bacterial strains.
ISSN:1413-8670
1678-4391
DOI:10.1590/S1413-86702010000400016