Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion

Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we gen...

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Bibliographic Details
Published in:Stem cell research 2018-07, Vol.30, p.81-84
Main Authors: Arioka, Yuko, Kushima, Itaru, Kubo, Hisako, Mori, Daisuke, Ozaki, Norio
Format: Article
Language:English
Subjects:
Aged
Glycoproteins - metabolism
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Male
Nerve Tissue Proteins - metabolism
Schizophrenia - metabolism
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Summary:Astrotactin-2, encoded by ASTN2, is implicated in neuronal migration. Although genetic studies of schizophrenia (SCZ) patients have suggested that exonic deletions of ASTN2 are associated with neurodevelopmental and psychiatric disorders, their biological significance remains unclear. Herein, we generated human induced pluripotent stem cells (iPSCs) from a SCZ patient with an exonic deletion of ASTN2. The generated iPSCs carried ASTN2 deletion and showed typical iPSC morphology, pluripotency marker expression, normal chromosomal aneuploidy, and the capacity to differentiate into three germ layers. This iPSC line may be suitable for evaluating Astrotactin-2 function relevant for SCZ onset in the human brain.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2018.05.013