Gastro-protective effect of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulcer in Wistar rats

• Published in: Toxicology reports 2017-01, Vol.4, p.625-633
• Main Authors: Adefisayo, Modinat A, Akomolafe, Rufus O, Akinsomisoye, Stephen O, Alabi, Quadri K, Ogundipe, Olaofe L, Omole, Joseph G, Olamilosoye, Kehinde P
• Format: Article
• Language: English
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2017.11.004

This study investigated the protective effects of methanol extract of leaf (MEVA) on aspirin induced gastric ulcer in rats. Thirty Wistar rats, 150-200 g were divided into six groups as follows: Group 1 (control) rats received 2 mL/kg of propylene glycol for 28 consecutive days. Group 2 (Ulcer Control) received 150 mg/kg/day of aspirin suspended in 3 mL of 1% carboxymethylcellulose in water orally for 3 consecutive days during which the rats were fasted for the induction of ulcer. Group 3 received cimetidine at 100 mg/kg/day orally for 28 consecutive days and thereafter treated as group 2. Groups 4, 5 and 6 received MEVA orally at 200, 300 and 400 mg/kg/day respectively for 28 consecutive days and thereafter were treated with aspirin as group 2. All the animals were sacrifice at the end of the study to determine the gastric pH, gastric acidity, gastric ulcer score, haematological indices, superoxide dismutase (SOD) activity, reduced glutathione (GSH) and Lipid peroxidation (LPO) levels. The result showed that aspirin significantly (p