Altered behavioral and electrophysiological responses to social fairness in manic and euthymic patients with bipolar disorder

Background Individuals with bipolar disorder show mood instability, including heightened anger and impulsivity. The Ultimatum Game (UG) is a tool used to evaluate emotional and social decision‐making strategies. We investigated behavioral and electrophysiological responses to subjectively fair or un...

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Published in:Brain and behavior 2021-08, Vol.11 (8), p.e2289-n/a
Main Authors: Ryu, Vin, Ha, Ra Yeon, Cho, Hyun‐Sang
Format: Article
Language:English
Subjects:
Aggressiveness
Altruism
Anger
Bipolar disorder
Decision making
Electroencephalography
Feedback
feedback‐related negativity
Game theory
Mental disorders
Mental health
Original Research
rejection rate
ultimatum game
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Ha, Ra Yeon
Cho, Hyun‐Sang
description Background Individuals with bipolar disorder show mood instability, including heightened anger and impulsivity. The Ultimatum Game (UG) is a tool used to evaluate emotional and social decision‐making strategies. We investigated behavioral and electrophysiological responses to subjectively fair or unfair offers in the UG in patients with bipolar I disorder. Methods Twenty‐four manic patients, 20 euthymic patients, and 30 healthy controls participated in this study. We analyzed their behaviors and collected electroencephalography data with which to analyze feedback‐related negativity (FRN) as they played in the UG as responders. Results Manic patients exhibited significantly higher rejection rates for unfair offers than euthymic patients and healthy controls. Healthy individuals exhibited a greater (i.e., more negative) FRN amplitude in response to unfair offers than to fair offers, whereas euthymic patients exhibited a greater FRN amplitude in response to fair offers compared with unfair offers. Manic patients exhibited no difference in FRN amplitudes between fair and unfair offers. Conclusions The current data suggest that different behavioral responses and FRN amplitude patterns can be associated with characteristic manifestations of mood instability in manic bipolar patients. In addition, electrophysiological alterations in response to unfair offers may be a trait abnormality independent of mood state. We found FRN response changes with higher rejection rates during ultimatum game in bipolar patients.
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The Ultimatum Game (UG) is a tool used to evaluate emotional and social decision‐making strategies. We investigated behavioral and electrophysiological responses to subjectively fair or unfair offers in the UG in patients with bipolar I disorder. Methods Twenty‐four manic patients, 20 euthymic patients, and 30 healthy controls participated in this study. We analyzed their behaviors and collected electroencephalography data with which to analyze feedback‐related negativity (FRN) as they played in the UG as responders. Results Manic patients exhibited significantly higher rejection rates for unfair offers than euthymic patients and healthy controls. Healthy individuals exhibited a greater (i.e., more negative) FRN amplitude in response to unfair offers than to fair offers, whereas euthymic patients exhibited a greater FRN amplitude in response to fair offers compared with unfair offers. Manic patients exhibited no difference in FRN amplitudes between fair and unfair offers. Conclusions The current data suggest that different behavioral responses and FRN amplitude patterns can be associated with characteristic manifestations of mood instability in manic bipolar patients. In addition, electrophysiological alterations in response to unfair offers may be a trait abnormality independent of mood state. We found FRN response changes with higher rejection rates during ultimatum game in bipolar patients.</description><identifier>ISSN: 2162-3279</identifier><identifier>EISSN: 2162-3279</identifier><identifier>DOI: 10.1002/brb3.2289</identifier><identifier>PMID: 34291610</identifier><language>eng</language><publisher>Los Angeles: John Wiley &amp; Sons, Inc</publisher><subject>Aggressiveness ; Altruism ; Anger ; Bipolar disorder ; Decision making ; Electroencephalography ; Feedback ; feedback‐related negativity ; Game theory ; Mental disorders ; Mental health ; Original Research ; rejection rate ; ultimatum game</subject><ispartof>Brain and behavior, 2021-08, Vol.11 (8), p.e2289-n/a</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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The Ultimatum Game (UG) is a tool used to evaluate emotional and social decision‐making strategies. We investigated behavioral and electrophysiological responses to subjectively fair or unfair offers in the UG in patients with bipolar I disorder. Methods Twenty‐four manic patients, 20 euthymic patients, and 30 healthy controls participated in this study. We analyzed their behaviors and collected electroencephalography data with which to analyze feedback‐related negativity (FRN) as they played in the UG as responders. Results Manic patients exhibited significantly higher rejection rates for unfair offers than euthymic patients and healthy controls. Healthy individuals exhibited a greater (i.e., more negative) FRN amplitude in response to unfair offers than to fair offers, whereas euthymic patients exhibited a greater FRN amplitude in response to fair offers compared with unfair offers. Manic patients exhibited no difference in FRN amplitudes between fair and unfair offers. 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subjects Aggressiveness
Altruism
Anger
Bipolar disorder
Decision making
Electroencephalography
Feedback
feedback‐related negativity
Game theory
Mental disorders
Mental health
Original Research
rejection rate
ultimatum game
title Altered behavioral and electrophysiological responses to social fairness in manic and euthymic patients with bipolar disorder
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