The Application of the ThroLy Risk Assessment Model to Predict Venous Thromboembolism in Patients with Diffuse Large B-Cell Lymphoma

Background Patients with aggressive lymphomas are at higher risk for venous thromboembolism (VTE). ThroLy is a risk assessment model (RAM) derived to predict the occurrence of VTE in various types of lymphomas. In this study, we assess the clinical application of ThroLy RAM in a unified group of pat...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2021, Vol.27, p.10760296211045908-10760296211045908
Main Authors: Abdel-Razeq, Hikmat, Ma’koseh, Mohammad, Mansour, Asem, Bater, Rayan, Amarin, Rula, Abufara, Alaa, Halahleh, Khalid, Manassra, Mohammad, Alrwashdeh, Mohammad, Almomani, Mohammad, Zmaily, Mais
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Lymphoma
Lymphoma, Large B-Cell, Diffuse - complications
Male
Middle Aged
Neutropenia
Original Manuscript
Risk Assessment
Thromboembolism
Venous Thromboembolism - etiology
Venous Thromboembolism - pathology
Young Adult
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Summary:Background Patients with aggressive lymphomas are at higher risk for venous thromboembolism (VTE). ThroLy is a risk assessment model (RAM) derived to predict the occurrence of VTE in various types of lymphomas. In this study, we assess the clinical application of ThroLy RAM in a unified group of patients with diffuse large B-cell lymphoma (DLBCL). Methods Hospital databases were searched for patients with DLBCL and radiologically-confirmed VTE. Items in the ThroLy RAM, including prior VTE, reduced mobility, obesity, extranodal disease, mediastinal involvement, neutropenia and hemoglobin  3) ThroLy score, 22.3% developed VTE compared to 8.4% and 12.4% in those with low and intermediate risk scores, respectively (P = .014). Simplifying the ThroLy model into two risk groups; high-risk (score ≥ 3) and low risk (score
ISSN:1076-0296
1938-2723
DOI:10.1177/10760296211045908