Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension

• Published in: Pulmonary circulation 2019-04, Vol.9 (2), p.1-10
• Main Authors: Bhattacharya, Priyanka T., Troutman, Gregory S., Mao, Frances, Fox, Arieh L., Tanna, Monique S., Zamani, Payman, Grandin, E. Wilson, Menachem, Jonathan N., Birati, Edo Y., Chirinos, Julio A., Mazimba, Sula, Smith, Kerri Akaya, Kawut, Steven M., Forfia, Paul R., Vaidya, Anjali, Mazurek, Jeremy A.
• Format: Article
• Language: English
• Subjects: Cpc‐PH; non‐invasive; pulmonary arterial compliance; Pulmonary arteries; Pulmonary hypertension
• ISSN: 2045-8940; 2045-8932; 2045-8940
• DOI: 10.1177/2045894019841978

Pulmonary arterial compliance (PAC), invasively assessed by the ratio of stroke volume to pulmonary arterial (PA) pulse pressure, is a sensitive marker of right ventricular (RV)-PA coupling that differs across the spectrum of pulmonary hypertension (PH) and is predictive of outcomes. We assessed whether the echocardiographically derived ratio of RV outflow tract velocity time integral to PA systolic pressure (RVOT-VTI/PASP) (a) correlates with invasive PAC, (b) discriminates heart failure with preserved ejection-associated PH (HFpEF-PH) from pulmonary arterial hypertension (PAH), and (c) is associated with functional capacity. We performed a retrospective cohort study of patients with PAH (n = 70) and HFpEF-PH (n = 86), which was further dichotomized by diastolic pressure gradient (DPG) into isolated post-capillary PH (DPG