The effect of hippocampal NR2B-containing NMDA receptors on chronic cognitive dysfunction in rats with temporal lobe epilepsy

BackgroundWe have previously reported that hippocampal long-term potentiation (LTP) was suppressed in temporal lobe epilepsy (TLE) rats. The N-methyl-D-aspartic acid receptors containing 2B subunit (NR2B-NMDARs) are indispensable to induce the LTP of hippocampus. However, it is still unknown whether...

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Bibliographic Details
Published in:Acta epileptologica 2023-01, Vol.5 (1), p.1-6, Article 1
Main Authors: Luo, Xiaoqing, Li, Cheng, Yu, Xiaoli, Kuang, Guangtao, Wang, Xiaolu, Liang, Jufang, Jiang, Jun
Format: Article
Language:English
Subjects:
Animal cognition
Antibodies
Chronic cognitive dysfunction
Cognitive ability
Convulsions & seizures
Epilepsy
Executive function
Hippocampus
Learning and memory
Memory
NR2B-containing NMDA receptors
Pathogenesis
Phosphorylation
Proteins
Software
Stainless steel
Temporal lobe epilepsy
Variance analysis
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Summary:BackgroundWe have previously reported that hippocampal long-term potentiation (LTP) was suppressed in temporal lobe epilepsy (TLE) rats. The N-methyl-D-aspartic acid receptors containing 2B subunit (NR2B-NMDARs) are indispensable to induce the LTP of hippocampus. However, it is still unknown whether the NR2B-NMDARs are implied with the cognitive dysfunction in TLE rats.MethodsThe TLE model was lithium chloride-pilocarpine (li-pilo) model. Morris water maze test was used to evaluate the cognitive function of epileptic rats. Expression of hippocampal NR2B-NMDAs was evaluated by western blotting. Stereotactic injection of NMDA, an agonist of NR2B-NMDARs, into the hippocampus of TLE rats was used to investigate the role of NR2B-NMDARs on cognitive dysfunction.ResultsCognitive function TLE rats was significantly reduced compared with controls in the Morris water maze test (P 
ISSN:2524-4434
2524-4434
DOI:10.1186/s42494-022-00111-2