Impact of acute hyperglycemic crisis episode on survival in individuals with diabetic foot ulcer using a machine learning approach

The outcome of DFUs concomitant with HCE remains unknown. This study aimed to investigate mortality rates and identify risk factors of mortality in patients with DFUs-HCE. 27 inpatients with DFUs-HCE were retrospectively enrolled in a cohort design, they were compared to 93 inpatients with DFUs in a...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2022-08, Vol.13, p.974063-974063
Main Authors: Deng, Liling, Xie, Puguang, Chen, Yan, Rui, Shunli, Yang, Cheng, Deng, Bo, Wang, Min, Armstrong, David G, Ma, Yu, Deng, Wuquan
Format: Article
Language:English
Subjects:
Cohort Studies
Diabetes Mellitus
Diabetic Foot - therapy
diabetic foot ulcer
Diabetic Neuropathies
Endocrinology
Humans
hyperglycemic crisis episode
Machine Learning
mortality rates
Retrospective Studies
risk factors of mortality
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Summary:The outcome of DFUs concomitant with HCE remains unknown. This study aimed to investigate mortality rates and identify risk factors of mortality in patients with DFUs-HCE. 27 inpatients with DFUs-HCE were retrospectively enrolled in a cohort design, they were compared to 93 inpatients with DFUs in a city designated emergency center, between January 2016 and January 2021. After a 6-year followed-up, clinical characteristic, amputation and survival rates were compared. Extreme gradient boosting was further used to explore the relative importance of HCE and other risk factors to all-cause mortality in DFUs. Patients with DFUs-HCE were more likely to havedementia, acute kidney injury and septic shock, whereas DFUs were more likely to have diabetic peripheral neuropathy and ulcer recurrence (P
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.974063