Investigation into the biocompatibility and antibacterial performance of TiO2 silicone nanocomposites

Incorporation of nanoparticles into silicone elastomers to form silicone nanocomposites is an area of ongoing research, with a broad range of biomedical applications. Addition-cure silicone nanocomposite dispersions were prepared, containing TiO2 of varying nanoparticle sizes and concentrations. All...

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Bibliographic Details
Published in:British Journal of Pharmacy 2022-11, Vol.7 (2), p.S1-S2
Main Authors: Quinn, James, Guimier, Eugénie, Carson, Louise, Malcolm, Karl
Format: Article
Language:English
Subjects:
antibacterial
Antibacterial agents
Biocompatibility
Biomedical materials
nanocomposite
Nanocomposites (Materials)
silicone
Silicones in medicine
tio2
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Summary:Incorporation of nanoparticles into silicone elastomers to form silicone nanocomposites is an area of ongoing research, with a broad range of biomedical applications. Addition-cure silicone nanocomposite dispersions were prepared, containing TiO2 of varying nanoparticle sizes and concentrations. All TiO2 silicone nanocomposites remained biocompatible (cell viability >70% relative to control silicone) when assessed via direct contact MTT assay. However, results from bacterial adherence studies demonstrated that 1000 nm and 200 nm TiO2 nanocomposites displayed a greater antibacterial effect in comparison to 100 nm and 20 nm TiO2 nanocomposites. The data suggests TiO2 silicone nanocomposites possess antibacterial properties (that is dependent on particle size) and are cytocompatible, warranting further research into potential uses for biomedical applications.
ISSN:2058-8356
2058-8356
DOI:10.5920/bjpharm.1125