Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study

The link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metab...

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Bibliographic Details
Published in:Nutrition journal 2020-06, Vol.19 (1), p.53-53, Article 53
Main Authors: Mlodzik-Czyzewska, Monika A, Malinowska, Anna M, Chmurzynska, Agata
Format: Article
Language:English
Subjects:
Abdominal Fat
Adipose tissue
Body fat
Body Mass Index
Body weight
Body weight gain
Case-Control Studies
DHFR
Diet
Dihydrofolate reductase
EDTA
Enzyme-linked immunosorbent assay
Enzymes
Folate
Folic Acid
Food
Genetic diversity
Genotype
Genotype & phenotype
Genotyping
Health risk assessment
High performance liquid chromatography
Homocysteine
Humans
Metabolism
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
MTHFR
Nutrition research
Obesity
Overweight
Physiological aspects
Regression analysis
Serum levels
Software
Statistics
Vitamin B
Womens health
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Summary:The link between folate metabolism and obesity has recently been underlined, suggesting that folate deficiency may lead to body weight gain and adiposity. We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. A case-control study including 421 healthy participants (aged 20-40) was performed in Poznań, Poland. The cases were 213 subjects with BMI > 25 kg/m , while the controls were 208 subjects with BMI 
ISSN:1475-2891
1475-2891
DOI:10.1186/s12937-020-00572-6