A Population Pharmacokinetic Approach to Describe Cephalexin Disposition in Adult and Aged Dogs

This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach. Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used....

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Bibliographic Details
Published in:Veterinary medicine international 2014, Vol.2014 (2014), p.1-7
Main Authors: Rebuelto, Marcela, Tarragona, Lisa, Quaine, Pamela, Monfrinotti, Agustina, Kreil, Verónica, Schaiquevich, Paula, Prados, Ana Paula, Hallu, Ruben
Format: Article
Language:English
Subjects:
Antibiotics
Aqueous solutions
Cephalexin
Complications and side effects
Dogs
Dosage and administration
Drug dosages
Genetic aspects
Geriatrics
Pharmacokinetics
Physiological aspects
Population
Rodents
Studies
Veterinary medicine
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Summary:This study was conducted in order to characterize the pharmacokinetics of orally administered cephalexin to healthy adult and aged dogs, using a population pharmacokinetic approach. Two hundred and eighty-six cephalexin plasma concentrations obtained from previous pharmacokinetic studies were used. Sex, age, pharmaceutical formulation, and breed were evaluated as covariates. A one-compartment model with an absorption lag-time (Tlag) best described the data. The final model included age (adult; aged) on apparent volume of distribution (Vd/F), apparent elimination rate (ke/F), and Tlag; sex (female; male) on ke/F, and breed (Beagle; mixed-breed) on Vd/F. Addition of the covariates to the model explained 78% of the interindividal variability (IIV) in Vd/F, 36% in ke/F, and 24% in Tlag, respectively. Formulation did not affect the variability of any of the pharmacokinetic parameters. Tlag was longer, whereas Vd/F and ke/F were lower in aged compared to adult animals; in female aged dogs ke/F was lower than in male aged dogs; however, the differences were of low magnitude. Different disposition of cephalexin may be expected in aged dogs.
ISSN:2090-8113
2042-0048
2042-0048
DOI:10.1155/2014/789353