Hyperbilirubinaemia after cardiac surgery: the point of no return

Aims The occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post‐operative heart failure is fairly common. We investigated the incidence, predictive value, and post‐operative outcome of hyperbilirubinaemia after cardiac surgery in an effort to identify potential ri...

Full description

Saved in:
Bibliographic Details
Published in:ESC Heart Failure 2019-08, Vol.6 (4), p.694-700
Main Authors: Farag, Mina, Veres, Gabor, Szabó, Gabor, Ruhparwar, Arjang, Karck, Matthias, Arif, Rawa
Format: Article
Language:English
Subjects:
Age
Aged
Angina pectoris
Angioplasty
Cardiopulmonary Bypass
Chronic obstructive pulmonary disease
Diabetes
Female
Heart attacks
Heart failure
Heart surgery
Hemodialysis
Humans
Hyperbilirubinaemia
Hyperbilirubinemia - epidemiology
Incidence
Intubation
Laboratories
Liver diseases
Liver failure
Low‐output syndrome
Male
Medical prognosis
Middle Aged
Mortality
Obesity
Original
Original s
Patients
Postoperative Complications - epidemiology
Prognosis
Prospective Studies
Pulmonary arteries
Pulmonary hypertension
Risk Assessment
Risk Factors
Statistical analysis
Survival analysis
Time Factors
Ventilators
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims The occurrence of hyperbilirubinaemia after heart surgery using cardiopulmonary bypass or post‐operative heart failure is fairly common. We investigated the incidence, predictive value, and post‐operative outcome of hyperbilirubinaemia after cardiac surgery in an effort to identify potential risk factors and significance on clinical outcome. Methods and results Between 2006 and 2016, 1272 (10.1%) out of 12 556 patients developed hyperbilirubinaemia, defined as bilirubin concentration >3 mg/dL, during post‐operative course at our institution. All patients who were operated using cardiopulmonary bypass were included. Hepatic dysfunction was diagnosed preoperatively in 200 patients (15.7%), whereas mean model of end‐stage liver disease score was 11.22 ± 4.99. Early mortality was 17.4% with age [hazard ratio (HR) 1.019, 95% confidence interval (CI) 1.008–1.029; P = 0.001], diabetes (HR 1.115, CI 1.020–1.220; P = 0.017), and emergent procedures (HR 1.315, CI 1.012–1.710) as multivariate predictors. Post‐operative predictors were low‐output syndrome (HR 3.193, 95% CI 2.495–4.086; P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12447