Loading…

Ultratrace element contents in rat tissues: Comparative analysis of serum and hair as indicative matrices of the total body burden

The aim of this study was to investigate the distribution of ultratrace elements in rat tissues and to perform a comparative analysis of hair and serum as potential bioindicators of the total ultratrace element content. Thirty-six male Wistar rats were fed a standard chow containing 0.006?0.000, 0.0...

Full description

Saved in:
Bibliographic Details
Published in:Archives of biological sciences 2016, Vol.68 (3), p.623-632
Main Authors: Skalny, Anatoly, Tinkov, Alexey, Skalny, Andrey, Medvedeva, Yulia, Alchinova, Irina, Ajsuvakova, Olga, Karganov, Mikhail, Nikonorov, Alexandr
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate the distribution of ultratrace elements in rat tissues and to perform a comparative analysis of hair and serum as potential bioindicators of the total ultratrace element content. Thirty-six male Wistar rats were fed a standard chow containing 0.006?0.000, 0.001?0.000, 0.017?0.002, 0.382?0.031, 0.168?0.014, 3.211?0.134, 0.095?0.006, 0.000?0.000, 6.675?0.336, 15.327?0.564, 0.002?0.000, and 1.185?0.202 ?g/g of silver (Ag), gold (Au), cesium (Cs), gallium (Ga), germanium (Ge), lanthanum (La), niobium (Nb), platinum (Pt), rubidium (Rb), titanium (Ti), thallium (Tl)and zirconium (Zr), respectively, from weaning to 3 months old. The ultratrace element content in the liver, kidney, muscle, heart, serum and hair was assessed using inductively coupled plasma mass spectrometry. The obtained data indicate that the highest concentrations of most of the studied elements (Ti, Zr, Ge, Nb, tungsten (W), La, uranium (U), Ag, Au, Pt) are in hair, whereas the lowest were observed in the serum. Statistical analysis revealed a significant association between concentrations in the hair and other tissues for Cs, Ti, Nb, Tl, La, U and Au. At the same time, serum Cs, Rb, Ti, Ge, Nb, W, Ga, Tl and La concentrations significantly correlated with the tissue content of the respective ultratrace elements. It can be concluded that hair may be used as a potential bioindicator for certain ultratrace element content in the mammalian organism. nema
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS150929053S