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MG1 interacts with a protease inhibitor and confers resistance to rice root-knot nematode

The rice root-knot nematode ( Meloidogyne graminicola ) is one of the most destructive pests threatening rice ( Oryza sativa L.) production in Asia; however, no rice resistance genes have been cloned. Here, we demonstrate that M. GRAMINICOLA-RESISTANCE GENE 1 ( MG1 ), an R gene highly expressed at t...

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Published in:Nature communications 2023-06, Vol.14 (1), p.3354-3354, Article 3354
Main Authors: Wang, Xiaomin, Cheng, Rui, Xu, Daochao, Huang, Renliang, Li, Haoxing, Jin, Liang, Wu, Yufeng, Tang, Jiuyou, Sun, Changhui, Peng, Deliang, Chu, Chengcai, Guo, Xiaoli
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Language:English
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Summary:The rice root-knot nematode ( Meloidogyne graminicola ) is one of the most destructive pests threatening rice ( Oryza sativa L.) production in Asia; however, no rice resistance genes have been cloned. Here, we demonstrate that M. GRAMINICOLA-RESISTANCE GENE 1 ( MG1 ), an R gene highly expressed at the site of nematode invasion, determines resistance against the nematode in several rice varieties. Introgressing MG1 into susceptible varieties increases resistance comparable to resistant varieties, for which the leucine-rich repeat domain is critical for recognizing root-knot nematode invasion. We also report transcriptome and cytological changes that are correlated with a rapid and robust response during the incompatible interaction that occurs in resistant rice upon nematode invasion. Furthermore, we identified a putative protease inhibitor that directly interacts with MG1 during MG1 -mediated resistance. Our findings provide insight into the molecular basis of nematode resistance as well as valuable resources for developing rice varieties with improved nematode resistance. Rice root-knot nematode is a major threat to rice production. Here, the authors identify an R gene MG1 in rice that confers resistance against nematodes and encodes a protein that interacts with a protease inhibitor.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-39080-6