Protein lysine crotonylation in cellular processions and disease associations

Protein lysine crotonylation (Kcr) is one conserved form of posttranslational modifications of proteins, which plays an important role in a series of cellular physiological and pathological processes. Lysine ε-amino groups are the primary sites of such modification, resulting in four-carbon planar l...

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Bibliographic Details
Published in:Genes & diseases 2024-09, Vol.11 (5), p.101060, Article 101060
Main Authors: Zhao, Hongling, Han, Yang, Zhou, Pingkun, Guan, Hua, Gao, Shanshan
Format: Article
Language:English
Subjects:
Cell biology
Disease
Lysine crotonylation
Posttranslational modification
Review
Therapeutic target
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Summary:Protein lysine crotonylation (Kcr) is one conserved form of posttranslational modifications of proteins, which plays an important role in a series of cellular physiological and pathological processes. Lysine ε-amino groups are the primary sites of such modification, resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these residues. High levels of Kcr modifications have been identified on both histone and non-histone proteins. The present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological processes. In addition, given the importance of protein Kcr modification in disease onset and progression, the potential viability of Kcr regulators as therapeutic targets is elucidated.
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2023.06.029