Role of Callistemon citrinus Leaf Phytosomes Against Oxidative Stress and Inflammation in Rats Fed with a High-Fat-Fructose Diet

Phytosomes are used as vehicles that carry plant extracts. They exhibit biological activities and possess better bioavailability, bioabsorption, and lower toxicity than drugs. Obesity is an inflammatory state in which oxidative stress is present, which triggers severe effects on the body's orga...

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Bibliographic Details
Published in:Antioxidants 2024-10, Vol.13 (10), p.1263
Main Authors: Ortega-Pérez, Luis Gerardo, Hernández-Soto, José Armando, Padilla-Avalos, Osvaldo, Ayala-Ruiz, Luis Alberto, Magaña-Rodríguez, Oliver Rafid, Piñón-Simental, Jonathan Saúl, Aguilera-Méndez, Asdrúbal, Godínez-Hernández, Daniel, Rios-Chavez, Patricia
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-inflammatory agents
antioxidant
Antioxidants
Bioavailability
Biomarkers
Body fat
Callistemon citrinus
Chronic illnesses
Diabetes
Diet
Drug delivery systems
Enzymatic activity
Enzymes
Fructose
High fat diet
Inflammation
Laboratory animals
Leaves
Lipid peroxidation
Obesity
Oxidation
Oxidative stress
Plant extracts
Proteins
Reagents
Rodents
Toxicity
Weight control
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Summary:Phytosomes are used as vehicles that carry plant extracts. They exhibit biological activities and possess better bioavailability, bioabsorption, and lower toxicity than drugs. Obesity is an inflammatory state in which oxidative stress is present, which triggers severe effects on the body's organs. This study aimed to evaluate the impact of the extract and phytosomes of on oxidative stress and inflammation in the liver and heart of Wistar rats fed with a high-fat-fructose diet. Phytosomes containing the extract of leaves of were prepared. The antioxidant, pro-inflammatory enzymes, and biomarkers of oxidative stress were evaluated. Among the groups, only the high-fat-fructose group presented an increase in the COX-2, 5-LOX, and MPO inflammatory enzymes, while the XO enzyme exhibited decreased activity. The groups were fed a hypercaloric diet for 15 weeks while orlistat, extract, and phytosomes were administered at three different concentrations, exhibiting enzyme activities similar to those of the control group. It was also observed that the lowest concentration of phytosomes had a comparable effect to the other concentrations. extract can modulate the activities of enzymes involved in the inflammation process. Furthermore, small doses of phytosomes can serve as anti-inflammatory agents.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13101263