Alterations in local activity and functional connectivity in patients with postherpetic neuralgia after short-term spinal cord stimulation

Objective: This study aimed to investigate the effect of therapy with peripheral nerve stimulation (PNS) and pulsed radiofrequency (PRF) combined or PNS and PRF separately in patients with herpes zoster ophthalmicus (HZO). Methods: This cohort study included 106 cases of HZO. Three groups were ident...

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Published in:Frontiers in molecular neuroscience 2022-08, Vol.15, p.938280-938280
Main Authors: Fan, Xiaochong, Ren, Huan, Bu, Chunxiao, Lu, Zhongyuan, Wei, Yarui, Xu, Fuxing, Fu, Lijun, Ma, Letian, Kong, Cunlong, Wang, Tao, Zhang, Yong, Liu, Qingying, Huang, Wenqi, Bu, Huilian, Yuan, Jingjing
Format: Article
Language:English
Subjects:
Electrodes
emotion
functional magnetic resonance imaging
Herpes zoster
Herpes zoster ophthalmicus
Magnetic resonance imaging
mechanisms of action
Medical imaging
Molecular Neuroscience
Neuralgia
Neuroimaging
Pain
Patients
Peripheral nerves
postherpetic neuralgia
Spinal cord
spinal cord stimulation
Time series
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Summary:Objective: This study aimed to investigate the effect of therapy with peripheral nerve stimulation (PNS) and pulsed radiofrequency (PRF) combined or PNS and PRF separately in patients with herpes zoster ophthalmicus (HZO). Methods: This cohort study included 106 cases of HZO. Three groups were identified according to the type of treatment received: combination therapy ( PNS + PRF ) ( n = 38 ), PRF ( n = 37 ), and PNS ( n = 31 ). The observations at 0, 1, 2, 4 weeks; 3 and 6 months; and 1 and 2 years after the operation were extracted and analyzed. Observations at each follow-up included baseline characteristics, NRS and the Pittsburgh Sleep Quality Index (PSQI), concomitant pain medication usage, relapse rate and adverse events. Results: The postoperative NRS of all three groups were significantly lower than preoperative scores. The PSQI of the three groups was significantly improved postoperatively, and the concomitant pain medication gradually decreased. Regarding long-term efficacy, the pain NRS and PSQI scores of the PNS + PRF and PNS groups were significantly lower than those of the PRF group (P
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2022.938280