Assessment of short-term effect of platelet-rich plasma treatment of tendinosis using texture analysis of ultrasound images

• Published in: Radiology and oncology 2023-12, Vol.57 (4), p.465-472
• Main Authors: Pintaric, Karlo, Salapura, Vladka, Snoj, Ziga, Vovk, Andrej, Mijovski, Mojca Bozic, Vidmar, Jernej
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Diagnostic tests; Female; Humans; Male; Matrix methods; Medical imaging; Middle Aged; Monitoring methods; Musculoskeletal diseases; Patients; Pilot Projects; platelet-rich plasma; Platelet-Rich Plasma - diagnostic imaging; Platelets; Quantitative analysis; Questionnaires; Statistical analysis; Tendinopathy - diagnostic imaging; Tendinopathy - therapy; tendinosis; Tendons; Texture; texture analysis; Tissues; Treatment Outcome; Ultrasonic imaging; Ultrasonography; Ultrasound
• ISSN: 1581-3207; 1318-2099; 1581-3207; 0485-893X
• DOI: 10.2478/raon-2023-0054

Computer-aided diagnosis ( , texture analyses) tools are becoming increasingly beneficial methods to monitor subtle tissue changes. The aim of this pilot study was to investigate short-term effect of platelet rich plasma (PRP) treatment in supraspinatus and common extensor of the forearm tendinosis by using texture analysis of ultrasound (US) images as well as by clinical questionnaires. Thirteen patients (7 male and 6 female, age 36-60 years, mean age 51.2 ± 5.2) were followed after US guided PRP treatment for tendinosis of two tendons (9 patients with lateral epicondylitis and 4 with supraspinatus tendinosis). Clinical and US assessment was performed prior to as well as 3 months after PRP treatment with validated clinical questionnaires. Tissue response in tendons was assessed by using gray level run length matrix method (GLRLM) of US images. All patients improved of tendinosis symptoms after PRP treatment according to clinical questionnaires. Almost all GLRLM features were statistically improved 3 months after PRP treatment. GLRLM-long run high gray level emphasis (LRLGLE) revealed the best moderate positive and statistically significant correlation after PRP ( = 0.4373, = 0.0255), followed by GLRLM-low gray level run emphasis (LGLRE) ( = 0.3877, = 0.05). Texture analysis of tendinosis US images was a useful quantitative method for the assessment of tendon remodeling after minimally invasive PRP treatment. GLRLM features have the potential to become useful imaging biomarkers to monitor spatial and time limited tissue response after PRP, however larger studies with similar protocols are needed.