Antimicrobial Ellagitannin of Punica granatum Fruits

The ethyl acetate extract of Punica granatum fruits was fractionated by chromatographic techniques to afford the ellagitannin punicalagin. The substance was found to be active against methicillin-resistant Staphylococcus aureus strains and was identified by HPLC/UV and ¹HNMR. The antibacterial assay...

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Bibliographic Details
Published in:Journal of the Brazilian Chemical Society 2002-09, Vol.13 (5), p.606-610
Main Authors: Machado, Thelma de B., Leal, Ivana C. R., Amaral, Ana Claudia F., Santos, Kátia R. N. dos, Silva, Marlei G. da, Kuster, Ricardo M.
Format: Article
Language:English
Subjects:
antimicrobial activity
CHEMISTRY, MULTIDISCIPLINARY
Punica granatum
punicalagin
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Summary:The ethyl acetate extract of Punica granatum fruits was fractionated by chromatographic techniques to afford the ellagitannin punicalagin. The substance was found to be active against methicillin-resistant Staphylococcus aureus strains and was identified by HPLC/UV and ¹HNMR. The antibacterial assays which guided the isolation of the tannin were conducted using the disc diffusion method. Minimum inhibitory concentration (MIC) was determined by the dilution method according to NCCLS (National Committee for Clinical Laboratory Standards) procedure.
ISSN:0103-5053
1678-4790
DOI:10.1590/S0103-50532002000500010