Association between neutrophil-to-albumin ratio and long-term mortality of aneurysmal subarachnoid hemorrhage

Objective The prognosis of aneurysmal subarachnoid hemorrhage (aSAH) survivors is concerning. The goal of this study was to investigate and demonstrate the relationship between the neutrophil-to-albumin ratio (NAR) and long-term mortality of aSAH survivors. Methods A retrospective observational coho...

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Published in:BMC neurology 2023-10, Vol.23 (1), p.1-374, Article 374
Main Authors: Zhang, Renjie, Zhang, Yu, Liu, Zheran, Pei, Yiyan, He, Yan, Yu, Jiayi, You, Chao, Ma, Lu, Fang, Fang
Format: Article
Language:English
Subjects:
Albumin
Analysis
Aneurysm
Aneurysms
Biomarkers
Forecasts and trends
Health aspects
Inflammation
Intracranial Aneurysm
Leukocytes (neutrophilic)
Medical imaging
Medical research
Medicine, Experimental
Mortality
Neutrophil-to-albumin
Prognosis
Regression analysis
Stroke
Stroke (Disease)
Subarachnoid Hemorrhage
Taiwan
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Summary:Objective The prognosis of aneurysmal subarachnoid hemorrhage (aSAH) survivors is concerning. The goal of this study was to investigate and demonstrate the relationship between the neutrophil-to-albumin ratio (NAR) and long-term mortality of aSAH survivors. Methods A retrospective observational cohort study was conducted at Sichuan University West China Hospital between January 2009 and June 2019. The investigation of relationship between NAR and long-term mortality was conducted using univariable and multivariable Cox regression models. To demonstrate the predictive performance of different biomarkers over time, time-dependent receiver operating characteristic curve (ROC) analysis and decision curve analysis (DCA) were created. Results In total, 3173 aSAH patients were included in this study. There was a strong and continuous relationship between NAR levels and long-term mortality (HR 3.23 95% CI 2.75-3.79, p < 0.001). After adjustment, the result was still significant (adjusted HR 1.78 95% CI 1.49-2.12). Compared with patients with the lowest quartile (< 0.15) of NAR levels, the risk of long-term mortality in the other groups was higher (0.15-0.20: adjusted HR 1.30 95% CI 0.97-1.73; 0.20-0.28: adjusted HR 1.37 95% CI 1.03-1.82; >0.28: adjusted HR 1.74 95% CI 1.30-2.32). Results in survivors were found to be still robust. Moreover, out of all the inflammatory markers studied, NAR demonstrated the highest correlation with long-term mortality. Conclusions A high level of NAR was associated with increased long-term mortality among patients with aSAH. NAR was a promising inflammatory marker for long-term mortality of aSAH. Keywords: Intracranial Aneurysm, Subarachnoid Hemorrhage, Prognosis, Neutrophil-to-albumin, Mortality
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-023-03433-x