Current Perspectives on Pyrroloiminoquinones: Distribution, Biosynthesis and Drug Discovery Potential

Pyrroloiminoquinones are a group of cytotoxic alkaloids most commonly isolated from marine sponges. Structurally, they are based on a tricyclic pyrrolo[4,3,2-de]quinoline core and encompass marine natural products such as makaluvamines, tsitsikammamines and discorhabdins. These diverse compounds are...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (24), p.8724
Main Authors: Kalinski, Jarmo-Charles J, Polyzois, Alexandros, Waterworth, Samantha C, Siwe Noundou, Xavier, Dorrington, Rosemary A
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - chemistry
Animals
Antifungal agents
Antiinfectives and antibacterials
Antineoplastic Agents - chemistry
Antiprotozoal agents
Antiviral agents
batzelline
Biological Products
Biosynthesis
Cancer
Cytotoxicity
damirone
discorhabdin
Drug development
Drug Discovery
Drug wholesalers
Enzymes
epinardin
Fungicides
Hydrocarbons
makaluvamine
Natural products
Physiological aspects
Porifera - chemistry
Pyrroloiminoquinones - chemistry
Pyrroloiminoquinones - pharmacology
Quinoline
Review
Sulfur
tsitsikammamine
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Summary:Pyrroloiminoquinones are a group of cytotoxic alkaloids most commonly isolated from marine sponges. Structurally, they are based on a tricyclic pyrrolo[4,3,2-de]quinoline core and encompass marine natural products such as makaluvamines, tsitsikammamines and discorhabdins. These diverse compounds are known to exhibit a broad spectrum of biological activities including anticancer, antiplasmodial, antimicrobial, antifungal and antiviral activities as well as the inhibition of several key cellular enzymes. The resurgence of interest in pyrroloiminoquinones and the convoluted understanding regarding their biological activities have prompted this review. Herein, we provided a concise summary of key findings and recent developments pertaining to their structural diversity, distribution, biogenesis, and their potential as chemical probes for drug development, including a discussion of promising synthetic analogs.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27248724