Persistent microscopic active inflammatory lesions in the central nervous system of a patient with neuromyelitis optica treated with oral prednisolone for more than 40 years

We have reported an autopsy case of neuromyelitis optica (NMO) that exhibited persisting active inflammatory lesions in the central nervous system (CNS) despite a 45-year-long treatment with oral corticosteroids. To our knowledge, our case had received the longest course of maintenance treatment. Th...

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Bibliographic Details
Published in:eNeurologicalSci 2018-06, Vol.11, p.17-19
Main Authors: Fujii, Chihiro, Itoh, Kyoko, Saito, Kozo, Satoh, Yu, Makino, Masahiro, Nakagawa, Masanori, Yamaguchi, Kyohei, Fushiki, Shinji, Mizuno, Toshiki
Format: Article
Language:English
Subjects:
Letters to the Editor
Long-term clinical course
Microscopic active inflammatory lesion
Neuromyelitis optica
Oral corticosteroid therapy
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Summary:We have reported an autopsy case of neuromyelitis optica (NMO) that exhibited persisting active inflammatory lesions in the central nervous system (CNS) despite a 45-year-long treatment with oral corticosteroids. To our knowledge, our case had received the longest course of maintenance treatment. This case study suggests that the current treatment of NMO with immunosuppressive agents may offer a good prospect for improving life expectancy. On the other hand, it also suggest that microscopic active lesions which were clinically silent and difficult to detect by neurological examination or MRI studies may persist in the CNS in patients with NMO, despite prolonged and continuous immunosuppressive treatment.
ISSN:2405-6502
2405-6502
DOI:10.1016/j.ensci.2018.05.005