Impact of Annual Exposure to Polycyclic Aromatic Hydrocarbons on Acute Exacerbation Frequency in Asthmatic Patients

Exposure to polycyclic aromatic hydrocarbons (PAHs) associated with ambient air particulate matter (PM) poses significant health concerns. Increased acute exacerbation (AE) frequency in asthmatic patients has been associated with ambient PAHs, but which subgroup of patients are particularly suscepti...

Full description

Saved in:
Bibliographic Details
Published in:Journal of asthma and allergy 2021-01, Vol.14, p.81-90
Main Authors: Lee, Shih-Wei, Huang, Yu-Chen, Lin, Chun-Yu, Huang, Hung-Yu, Liu, Chi-Wei, Hsieh, Ming-Tsuen, Lee, Chon-Lin, Chung, Wen-Yu, Chung, Kian Fan, Wang, Chun-Hua, Kuo, Han-Pin
Format: Article
Language:English
Subjects:
Air pollution
Air quality
Asthma
asthma acute exacerbation
Cardiovascular disease
Care and treatment
Correlation analysis
Emergency medical care
Environmental protection
Geographic information systems
gina
Hospitals
hourly grid-scale model
Original Research
Particulate matter
Patients
Pollutants
Polycyclic aromatic hydrocarbons
Principal components analysis
Regression analysis
Scale models
Simulation
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Exposure to polycyclic aromatic hydrocarbons (PAHs) associated with ambient air particulate matter (PM) poses significant health concerns. Increased acute exacerbation (AE) frequency in asthmatic patients has been associated with ambient PAHs, but which subgroup of patients are particularly susceptible to ambient PAHs is uncertain. We developed a new model to simulate grid-scale PM -PAH levels in order to evaluate whether the severity of asthma as measured by the Global Initiative of Asthma (GINA) levels of treatment is related to cumulative exposure of ambient PAHs. Patients with asthma residing in the northern Taiwan were reviewed retrospectively from 2014 to 2017. PM were sampled and analysed for PAHs twice a month over a 72-hour period, in addition to collecting the routinely monitored air pollutant data from an established air quality monitoring network. In combination with correlation analysis and principal component analysis, multivariate linear regression models were performed to simulate hourly grid-scale PM -PAH concentrations (ng/m ). A geographic information system mapping approach with ordinary kriging interpolation method was used to calculate the annual exposure of PAHs (ng/m). Among the 387 patients with asthma aged 18 to 93 (median 62), 97 subjects were treated as GINA step 5 (24%). Asthmatics in GINA 5 subgroup with high annual PAHs exposure were likely to have a higher annual frequency of any AE (1 (0-12), p
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S288052