Extracellular Vesicles of COVID-19 Patients Reflect Inflammation, Thrombogenicity, and Disease Severity

Severe COVID-19 infections present with cytokine storms, hypercoagulation, and acute respiratory distress syndrome, with extracellular vesicles (EVs) being involved in coagulation and inflammation. This study aimed to determine whether coagulation profiles and EVs reflect COVID-19 disease severity....

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Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (6), p.5918
Main Authors: Aharon, Anat, Dangot, Ayelet, Kinaani, Fadi, Zavaro, Mor, Bannon, Lian, Bar-Lev, Tali, Keren-Politansky, Anat, Avivi, Irit, Jacob, Giris
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Alzheimer's disease
Antigens
Biomarkers
Biomarkers - metabolism
CD14 antigen
CD4 antigen
CD63 antigen
CD8 antigen
Coagulation
Coagulation factors
Coronaviruses
COVID-19
COVID-19 - metabolism
Cytokine storm
Cytokines
Disease transmission
Exosomes
Extracellular vesicles
extracellular vesicles (EVs)
Extracellular Vesicles - metabolism
Fibrinogen
Flow cytometry
Health aspects
Humans
Immune system
Inflammation
Inflammation - metabolism
Interleukin 6
Medical prognosis
Nanoparticles
Patient Acuity
Patients
Protein C
Protein S
Proteins
Respiratory distress syndrome
Severe acute respiratory syndrome coronavirus 2
Thromboembolism
thrombogenicity
Tissue factor
Vesicles
Viral infections
Von Willebrand factor
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Description
Summary:Severe COVID-19 infections present with cytokine storms, hypercoagulation, and acute respiratory distress syndrome, with extracellular vesicles (EVs) being involved in coagulation and inflammation. This study aimed to determine whether coagulation profiles and EVs reflect COVID-19 disease severity. Thirty-six patients with symptomatic COVID-19 infection with mild/moderate/severe disease (12 in each group) were analyzed. Sixteen healthy individuals served as controls. Coagulation profiles and EV characteristics were tested by nanoparticle tracking analysis (NTA), flow cytometry, and Western blot. While coagulation factors VII, V, VIII, and vWF were comparable, significant differences were found in patients' D-Dimer/fibrinogen/free protein S levels compared to controls. Severe patients' EVs displayed higher percentages of small EVs (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24065918