Monoterpenoids from the Fruits of Amomum tsao-ko Have Inhibitory Effects on Nitric Oxide Production

In our search for novel plant-derived inhibitors of nitric oxide (NO) with potential for treating inflammatory diseases, the phytochemicals of fruits were investigated, leading to the isolation of one bicyclic nonane ( ), three menthene skeleton monoterpenoids ( - ), and two acyclic monoterpenoids (...

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Bibliographic Details
Published in:Plants (Basel) 2021-01, Vol.10 (2), p.257
Main Authors: Hong, Seong Su, Lee, Ji Eun, Jung, Yeon Woo, Park, Ju-Hyoung, Lee, Jung A, Jeong, Wonsik, Ahn, Eun-Kyung, Choi, Chun Whan, Oh, Joa Sub
Format: Article
Language:English
Subjects:
Amomum
Amomum tsao-ko
anti-inflammation
Carbon
Chromatography
Communication
Cytokines
Fruits
Inflammation
Inflammatory diseases
Interleukin 1
Interleukin 6
Interleukins
Lipopolysaccharides
Magnetic resonance spectroscopy
Mass spectrometry
Mass spectroscopy
menthene skeleton
Metabolites
Molecular weight
monoterpenoid
Monoterpenoids
Natural products
Nitric oxide
Nitric-oxide synthase
NMR
NMR spectroscopy
Nuclear magnetic resonance
Plants
Western blotting
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Summary:In our search for novel plant-derived inhibitors of nitric oxide (NO) with potential for treating inflammatory diseases, the phytochemicals of fruits were investigated, leading to the isolation of one bicyclic nonane ( ), three menthene skeleton monoterpenoids ( - ), and two acyclic monoterpenoids ( and ). Their structures were identified using one- and two-dimensional nuclear magnetic resonance spectroscopy, and mass spectrometry. To the best of our knowledge, compounds - were obtained from the genus for the first time. All isolates were tested for their ability to inhibit lipopolysaccharide-stimulated NO overproduction in RAW264.7 cells. Compound was found to inhibit NO production. Western blotting analysis indicated that active compound can regulate inducible NO synthase expression. In addition, lipopolysaccharide-induced interleukin 1 beta and interleukin-6 overproduction was reduced in a concentration-dependent manner.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants10020257