The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological Roles

Classically, osteopontin (OPN) has been described as a secreted glycophosprotein. Indeed, most data concerning its physiological and pathological roles are mainly related to the secreted OPN (sOPN). However, there are several instances in which intracellular OPN (iOPN) has been described, presenting...

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Published in:International journal of molecular sciences 2023-02, Vol.24 (3), p.2942
Main Authors: Bastos, Ana Clara Santos da Fonseca, Gomes, Amanda Vitória Pampolha, Silva, Gabriela Ribeiro, Emerenciano, Mariana, Ferreira, Luciana Bueno, Gimba, Etel Rodrigues Pereira
Format: Article
Language:English
Subjects:
Amino acids
Cancer
Immune system
Intracellular
intracellular osteopontin
Localization
Mineralization
Neurological diseases
Osteopontin
Osteopontin - genetics
Osteopontin - metabolism
osteopontin isoforms
Peptides
Phosphorylation
physio-pathological roles
Proteins
Review
RNA Splicing
secreted osteopontin
Severe acute respiratory syndrome coronavirus 2
Splicing
structure
Therapeutic applications
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Summary:Classically, osteopontin (OPN) has been described as a secreted glycophosprotein. Indeed, most data concerning its physiological and pathological roles are mainly related to the secreted OPN (sOPN). However, there are several instances in which intracellular OPN (iOPN) has been described, presenting some specific roles in distinct experimental models, such as in the immune system, cancer cells, and neurological disorders. We herein aimed to highlight and discuss some of these secreted and intracellular roles of OPN and their putative clinical and biological impacts. Moreover, by consolidating data from the OPN protein database, we also analyzed the occurrence of signal peptide (SP) sequences and putative subcellular localization, especially concerning currently known OPN splicing variants (OPN-SV). Comprehending the roles of OPN in its distinct cellular and tissue environments may provide data regarding the additional applications of this protein as biomarkers and targets for therapeutic purposes, besides further describing its pleiotropic roles.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24032942