Plasma long pentraxin 3 as a marker of endothelial dysfunction in early diabetic nephropathy

• Published in: The Egyptian journal of internal medicine 2013-07, Vol.25 (3), p.117-126
• Main Authors: El Meligi, Amr A., Hamid, Alaa M. Abdel, Aziz, Manal A., El Haddadd, Hemmat E., Ishak, Marian F., Yousief, Elham M.
• Format: Article
• Language: English
• Subjects: Diabetes; Diabetic nephropathy; endothelial dysfunction, long pentraxin 3, microalbuminuria, type 2 diabetes, vWF; Internal Medicine; Medicine & Public Health; Original Article
• ISSN: 1110-7782; 2090-9098
• DOI: 10.7123/01.EJIM.0000433328.59695.f9

Objective This study investigated the utility of measuring plasma long pentraxin 3 (PTX3) levels in the early detection of endothelial dysfunction compared with Von Willebrand factor (vWF) activity and flow-dependent arterial dilatation (well-known markers of endothelial dysfunction) in early diabetic nephropathy. Materials and methods A total of 50 Egyptian patients with type 2 diabetes and 20 healthy controls were recruited from the Diabetes, Endocrinology and Metabolism center, Faculty of Medicine, Cairo University. The diabetic patients were divided into two equal groups of comparable age and sex: group I consisted of patients with normal urinary albumin excretion and group II consisted of patients with microalbuminuria. Results In group II, the plasma PTX3 level was significantly higher (median value 2.3 ng/ml) and the mean flow-mediated dilatation (FMD; 0.433 ±0.059) was significantly lower when compared with the control group (PTX3 1.15 ng/ml, FMD 0.901 ± 0.04; P