Glycemic status, lipid profile and proteinuria in diabetic nephropathy

Diabetic nephropathy is one of the major complications of Diabetes Mellitus characterized by persistent albuminuria, elevated arterial blood pressure, a relentless decline in glomerular filtration rate (GFR) and a high risk of cardiovascular morbidity and mortality. In this study, urinary micro-albu...

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Bibliographic Details
Published in:Journal of Nepal Medical Association 2010-04, Vol.49 (178), p.143-146
Main Authors: Jha, P, Das, B K L, Shrestha, S, Majhi, S, Chandra, L, Sharma, S, Baral, N
Format: Article
Language:English
Subjects:
Adult
Aged
Albuminuria - complications
Blood Glucose - metabolism
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Creatinine - blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - urine
Diabetic Nephropathies - blood
Diabetic Nephropathies - etiology
Diabetic Nephropathies - urine
Female
Glycated Hemoglobin A - metabolism
Humans
Lipids - blood
Male
Middle Aged
Triglycerides - blood
Urea - blood
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Summary:Diabetic nephropathy is one of the major complications of Diabetes Mellitus characterized by persistent albuminuria, elevated arterial blood pressure, a relentless decline in glomerular filtration rate (GFR) and a high risk of cardiovascular morbidity and mortality. In this study, urinary micro-albumin estimation was done in 177 diabetic patients. This study aims to ascertain association of glycemic status, lipid profile and proteinuria in Type 2 Diabetes Mellitus with nephropathy. Among 177 patients, 26 had frank proteinuria, 79 had micro-albuminuria and 72 were without proteinuria. Increased frequency of proteinuria was seen in male than female. Micro-albuminuria and frank proteinuria was seen more in older age group. The multiple comparisons showed the significantly increased levels of urea, creatinine, fasting blood glucose in micro-albuminuria and overt proteinuria patients in comparison to without proteinuria. Glycated hemoglobin level was increased with the increasing age group particularly in overt proteinuric patients. The glycemic control, monitoring of lipid profile and early urinary protein estimation with better management may delay diabetic nephropathy or its further complications in diabetes mellitus.
ISSN:0028-2715
1815-672X
DOI:10.31729/jnma.115