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Pericentric inversion in chromosome 1 and male infertility
Pericentric inversion in chromosome 1 was thought to cause male infertility through spermatogenic impairment, regardless of the breakpoint position. However, carriers of pericentric inversion in chromosome 1 have been reported with normal fertility and familial transmission. Here, we report two case...
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| Published in: | Open medicine (Warsaw, Poland) Poland), 2020-01, Vol.15 (1), p.343-348 |
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| container_title | Open medicine (Warsaw, Poland) |
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| creator | Li, Ranwei Fan, Haitao Zhang, Qiushuang Yang, Xiao Zhan, Peng Feng, Shuqiang |
| description | Pericentric inversion in chromosome 1 was thought to cause male infertility through
spermatogenic impairment, regardless of the breakpoint position. However, carriers of
pericentric inversion in chromosome 1 have been reported with normal fertility and
familial transmission. Here, we report two cases of pericentric inversion in
chromosome 1. One case was detected
via amniocentesis, and
the other case was detected after the wife of the carrier experienced two spontaneous
abortions within 5 years of marriage. Here, the effect of the breakpoint position of
the inversion in chromosome 1 on male infertility is examined and compared with the
published cases. The association between the breakpoint of pericentric inversion in
chromosome 1 and spermatogenesis is also discussed. Overall, the results suggest that
the breakpoint position deserves attention from physicians in genetic counseling as
inversion carriers can produce offspring. |
| doi_str_mv | 10.1515/med-2020-0404 |
| format | article |
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spermatogenic impairment, regardless of the breakpoint position. However, carriers of
pericentric inversion in chromosome 1 have been reported with normal fertility and
familial transmission. Here, we report two cases of pericentric inversion in
chromosome 1. One case was detected
via amniocentesis, and
the other case was detected after the wife of the carrier experienced two spontaneous
abortions within 5 years of marriage. Here, the effect of the breakpoint position of
the inversion in chromosome 1 on male infertility is examined and compared with the
published cases. The association between the breakpoint of pericentric inversion in
chromosome 1 and spermatogenesis is also discussed. Overall, the results suggest that
the breakpoint position deserves attention from physicians in genetic counseling as
inversion carriers can produce offspring.</description><identifier>ISSN: 2391-5463</identifier><identifier>EISSN: 2391-5463</identifier><identifier>DOI: 10.1515/med-2020-0404</identifier><identifier>PMID: 33335995</identifier><language>eng</language><publisher>Poland: De Gruyter</publisher><subject>chromosome 1 ; Chromosomes ; Genetic counseling ; Infertility ; male infertility ; Males ; pericentric inversion</subject><ispartof>Open medicine (Warsaw, Poland), 2020-01, Vol.15 (1), p.343-348</ispartof><rights>2020 Ranwei Li et al., published by De Gruyter.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Ranwei Li ., published by De Gruyter 2020 Ranwei Li et al., published De Gruyter</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-14132eeeee2b56a90694efe7eeeec34fbfa883b44e04b7d590f8c97035ec5ec93</citedby><cites>FETCH-LOGICAL-c533t-14132eeeee2b56a90694efe7eeeec34fbfa883b44e04b7d590f8c97035ec5ec93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712408/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712408/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792,67029,68813</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33335995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ranwei</creatorcontrib><creatorcontrib>Fan, Haitao</creatorcontrib><creatorcontrib>Zhang, Qiushuang</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Zhan, Peng</creatorcontrib><creatorcontrib>Feng, Shuqiang</creatorcontrib><title>Pericentric inversion in chromosome 1 and male infertility</title><title>Open medicine (Warsaw, Poland)</title><addtitle>Open Med (Wars)</addtitle><description>Pericentric inversion in chromosome 1 was thought to cause male infertility through
spermatogenic impairment, regardless of the breakpoint position. However, carriers of
pericentric inversion in chromosome 1 have been reported with normal fertility and
familial transmission. Here, we report two cases of pericentric inversion in
chromosome 1. One case was detected
via amniocentesis, and
the other case was detected after the wife of the carrier experienced two spontaneous
abortions within 5 years of marriage. Here, the effect of the breakpoint position of
the inversion in chromosome 1 on male infertility is examined and compared with the
published cases. The association between the breakpoint of pericentric inversion in
chromosome 1 and spermatogenesis is also discussed. Overall, the results suggest that
the breakpoint position deserves attention from physicians in genetic counseling as
inversion carriers can produce offspring.</description><subject>chromosome 1</subject><subject>Chromosomes</subject><subject>Genetic counseling</subject><subject>Infertility</subject><subject>male infertility</subject><subject>Males</subject><subject>pericentric inversion</subject><issn>2391-5463</issn><issn>2391-5463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUUFrFjEQDWKxpfboVRa8eFlNNpPsRkGQUrVQqAc9h2x29ms-djc12a18_76z_WptxSEkw8zjZd48xl4J_k4ood6P2JUVr3jJgcMzdlRJI0oFWj5_lB-yk5y3nHOhZG1q_oIdSgpljDpiH75jCh6nme4iTDeYcogTZYW_SnGMOY5YiMJNXTG6AanRY5rDEObdS3bQuyHjyf17zH5-Oftx-q28uPx6fvr5ovRKyrkUIGSFa1St0s5wbQB7rNeKl9C3vWsa2QIgh7bulOF942lMqdDTMfKYne95u-i29jqF0aWdjS7Yu0JMG-toJD-gBW08EYFqvALndGOU7IVoJCitNQBxfdpzXS8tLe9OuBuekD7tTOHKbuKNrWtRAW-I4O09QYq_FsyzHUP2OAxuwrhkW0EtQJNwRdA3_0C3cUkTrcqSN0CoRq3qyj3Kp5hzwv5hGMHtarKlaexqsl1NJvzrxwoe0H8sJcDHPeC3G2ZMHW7SsqPk7-__JaaKBClvAdN0tK8</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Li, Ranwei</creator><creator>Fan, Haitao</creator><creator>Zhang, Qiushuang</creator><creator>Yang, Xiao</creator><creator>Zhan, Peng</creator><creator>Feng, Shuqiang</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200101</creationdate><title>Pericentric inversion in chromosome 1 and male infertility</title><author>Li, Ranwei ; Fan, Haitao ; Zhang, Qiushuang ; Yang, Xiao ; Zhan, Peng ; Feng, Shuqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-14132eeeee2b56a90694efe7eeeec34fbfa883b44e04b7d590f8c97035ec5ec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>chromosome 1</topic><topic>Chromosomes</topic><topic>Genetic counseling</topic><topic>Infertility</topic><topic>male infertility</topic><topic>Males</topic><topic>pericentric inversion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ranwei</creatorcontrib><creatorcontrib>Fan, Haitao</creatorcontrib><creatorcontrib>Zhang, Qiushuang</creatorcontrib><creatorcontrib>Yang, Xiao</creatorcontrib><creatorcontrib>Zhan, Peng</creatorcontrib><creatorcontrib>Feng, Shuqiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Open medicine (Warsaw, Poland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ranwei</au><au>Fan, Haitao</au><au>Zhang, Qiushuang</au><au>Yang, Xiao</au><au>Zhan, Peng</au><au>Feng, Shuqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pericentric inversion in chromosome 1 and male infertility</atitle><jtitle>Open medicine (Warsaw, Poland)</jtitle><addtitle>Open Med (Wars)</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>343</spage><epage>348</epage><pages>343-348</pages><issn>2391-5463</issn><eissn>2391-5463</eissn><abstract>Pericentric inversion in chromosome 1 was thought to cause male infertility through
spermatogenic impairment, regardless of the breakpoint position. However, carriers of
pericentric inversion in chromosome 1 have been reported with normal fertility and
familial transmission. Here, we report two cases of pericentric inversion in
chromosome 1. One case was detected
via amniocentesis, and
the other case was detected after the wife of the carrier experienced two spontaneous
abortions within 5 years of marriage. Here, the effect of the breakpoint position of
the inversion in chromosome 1 on male infertility is examined and compared with the
published cases. The association between the breakpoint of pericentric inversion in
chromosome 1 and spermatogenesis is also discussed. Overall, the results suggest that
the breakpoint position deserves attention from physicians in genetic counseling as
inversion carriers can produce offspring.</abstract><cop>Poland</cop><pub>De Gruyter</pub><pmid>33335995</pmid><doi>10.1515/med-2020-0404</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | De Gruyter Open Access Journals; PubMed Central |
| subjects | chromosome 1 Chromosomes Genetic counseling Infertility male infertility Males pericentric inversion |
| title | Pericentric inversion in chromosome 1 and male infertility |
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