Does prior immunization with measles, mumps, and rubella vaccines contribute to the antibody response to COVID-19 antigens?

Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. To assess the cross-protection induced by prior measles, mump...

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Bibliographic Details
Published in:Iranian journal of immunology 2021-03, Vol.18 (1), p.47-53
Main Authors: Hassani, Danesh, Amiri, Mohammad Mehdi, Maghsood, Faezeh, Salimi, Vahid, Kardar, Gholam Ali, Barati, Omid, Hashemian, Seyed Mohammad Reza, Jeddi-Tehrani, Mahmood, Zarnani, Amir-Hassan, Shokri, Fazel
Format: Article
Language:English
Subjects:
Age Factors
Aged
Antibodies
Antibodies, Viral - blood
Antibody response
Antigens
Antigens, Viral - immunology
B-Lymphocytes - immunology
B-Lymphocytes - virology
Biomarkers - blood
Case-Control Studies
Children
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - diagnosis
COVID-19 - immunology
COVID-19 - virology
COVID-19 vaccines
Cross Protection
Cross Reactions
Female
Host-Pathogen Interactions
Humans
Immunization
Immunoglobulin G
Immunoglobulin G - blood
Infections
Lymphocytes B
Male
Measles
Measles-Mumps-Rubella Vaccine - immunology
Measles-Mumps-Rubella Vaccine - therapeutic use
Middle Aged
mmr
Mumps
Neonates
Rubella
SARS-CoV-2 - immunology
sars-cov2
Serum levels
Severe acute respiratory syndrome coronavirus 2
Tetanus
Tetanus Toxoid - immunology
Tetanus Toxoid - therapeutic use
Vaccines
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Summary:Incidence and severity of SARS-CoV2 infection are significantly lower in children and teenagers proposing that certain vaccines, routinely administered to neonates and children may provide cross-protection against this emerging infection. To assess the cross-protection induced by prior measles, mumps and rubella (MMR) vaccinations against COVID-19. The antibody responses to MMR and tetanus vaccines were determined in 53 patients affected with SARS-CoV2 infection and 52 age-matched healthy subjects. Serum levels of antibodies specific for NP and RBD of SARS-CoV2 were also determined in both groups of subjects with ELISA. Our results revealed significant differences in anti-NP (P
ISSN:1735-1383
1735-367X
DOI:10.22034/iji.2021.87990.1843