A promising α-glucosidase and α-amylase inhibitors based on benzimidazole-oxadiazole hybrid analogues: Evidence based in vitro and in silico studies

[Display omitted] The present study reports the design and synthesis of new benzimidazole-oxadiazole compounds as potent inhibitors of α-glucosidase and α-amylase. The synthesized molecules were characterized through different techniques such as 1HNMR, 13CNMR, HREI-MS and evaluated for their in vitr...

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Bibliographic Details
Published in:Results in Chemistry 2024-10, Vol.11, p.101832, Article 101832
Main Authors: Ullah, Hayat, Uddin, Imad, Ali, Hafeeza Zafar, Hassan, Wagma, Mehnaz, Gul, Maryam, Laiba, Sarfraz, Maliha, Khan, Muhammad Saleem, Islam, Mohammad Shahidul, Almarhoon, Zainab M., Iqbal, Rashid, Nabi, Muhammad
Format: Article
Language:English
Subjects:
Antidiabetic
Benzimidazole
Molecular Docking
Oxadiazole
SAR
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Summary:[Display omitted] The present study reports the design and synthesis of new benzimidazole-oxadiazole compounds as potent inhibitors of α-glucosidase and α-amylase. The synthesized molecules were characterized through different techniques such as 1HNMR, 13CNMR, HREI-MS and evaluated for their in vitro inhibitory activities against these enzymes. Among the compounds screened, compound 8 demonstrated the highest inhibitory activity against both α-glucosidase (IC50 = 11.60 µM) and α-amylase (IC50 = 6.20 µM). Molecular docking analyses were conducted to investigate the binding modes and interactions of the active compounds within the enzyme active sites. The results demonstrate that several benzimidazole-oxadiazole hybrids exhibited potent inhibitory effects on both α-glucosidase and α-amylase, suggesting their promise as antidiabetic agents.
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2024.101832