Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis

To study the efficacy of anti Cryptococcal treatment by cerebrospinal fluid (CSF) fungal negativity after two weeks of treatment with amphotericin B alone or combined with fluconazole in treatment of HIV associated Cryptococcal meningitis (CM). A total of 84 human immunodeficiency virus (HIV) associ...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2015-02, Vol.9 (2), p.OC14-OC16
Main Authors: Vaidhya, Shashank Anant, Gupta, Bharat Bhushan, Jha, Rajesh Kumar, Kumar, Ravindra
Format: Article
Language:English
Subjects:
amphotericin b
combination therapy
cryptococcal meningitis
fluconazole
hiv
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Summary:To study the efficacy of anti Cryptococcal treatment by cerebrospinal fluid (CSF) fungal negativity after two weeks of treatment with amphotericin B alone or combined with fluconazole in treatment of HIV associated Cryptococcal meningitis (CM). A total of 84 human immunodeficiency virus (HIV) associated CM patients confirmed by CSF culture positivity were recruited for the study. Patients were randomly divided into two groups. Group A was given amphotericin B alone whereas Amphotericin B in combination with fluconazole was given in group B for the treatment of CM. Patients were followed for 14 days. Maximum number of patients was in the age group 21-49 y. All the 84 patients had
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2015/12360.5601