p -Cymene Complexes of Ruthenium(II) as Antitumor Agents

• Published in: Molecules (Basel, Switzerland) Switzerland), 2020-10, Vol.25 (21), p.5063
• Main Authors: Pujante-Galián, María Angeles, Pérez, Sergio A, Montalbán, Mercedes G, Carissimi, Guzmán, Fuster, Marta G, Víllora, Gloria, García, Gabriel
• Format: Article
• Language: English
• Subjects: Aminophenol; Aminophenols - chemistry; anticancer activity; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Breast cancer; Carcinogens; Cell Proliferation - drug effects; Cervical cancer; Cervical carcinoma; Cervix; complexes; Coordination Complexes - chemical synthesis; Coordination Complexes - pharmacology; Cymenes - chemistry; Cytotoxicity; Drug dosages; Drug Screening Assays, Antitumor; Epithelial cells; Epithelium; Fibroblasts; HeLa Cells; Humans; Ligands; Mass spectrometry; MCF-7 Cells; MTT assay; Nitriles - chemistry; NMR; Nuclear magnetic resonance; Ovaries; p-Cymene; Pyridazines - chemistry; Pyridines - chemistry; Ruthenium; Ruthenium - chemistry; Ruthenium compounds; Scientific imaging; Selectivity; Stoichiometry; Tumors
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25215063

In this work, the cytotoxic behavior of six ruthenium(II) complexes of stoichiometry [(η - -cymene)RuCl L] (I-VI), L = 4-cyanopyridine (I), 2-aminophenol (II), 4-aminophenol (III), pyridazine (IV), and [( - -cymene)RuClL ]PF ; L = cyanopyridine (V), L = 2-aminophenol(VI) towards three cell lines was studied. Two of them, HeLa and MCF-7, are human carcinogenic cells from cervical carcinoma and human breast cancer, respectively. A comparison with healthy cells was carried out with BGM cells which are monkey epithelial cells of renal origin. The behavior of complex II exhibits selectivity towards healthy cells, which is a promising feature for use in cancer treatment since it might reduce the side effects of most current therapies.