Aligned electrospun polymer fibres for skeletal muscle regeneration

Skeletal muscle repair is often overlooked in surgical procedures and in serious burn victims. Creating a tissue-engineered skeletal muscle would not only provide a grafting material for these clinical situations, but could also be used as a valuable true-to-life research tool into diseases affectin...

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Bibliographic Details
Published in:European cells & materials 2010-05, Vol.19, p.193-204
Main Authors: Aviss, K J, Gough, J E, Downes, S
Format: Article
Language:English
Subjects:
alignment
Animals
Cell Adhesion
Cell Line
Cell Proliferation
Cell Shape
Electrospinning
Lactic Acid - chemistry
Lactic Acid - therapeutic use
Mice
Molecular Conformation
Muscle, Skeletal - injuries
Muscle, Skeletal - physiology
myoblasts
Myoblasts - cytology
PLGA
Polyglycolic Acid - chemistry
Polyglycolic Acid - therapeutic use
Polylactic Acid-Polyglycolic Acid Copolymer
Regeneration
Regenerative Medicine - methods
surface topography
Tissue Engineering - methods
Wound Healing
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Summary:Skeletal muscle repair is often overlooked in surgical procedures and in serious burn victims. Creating a tissue-engineered skeletal muscle would not only provide a grafting material for these clinical situations, but could also be used as a valuable true-to-life research tool into diseases affecting muscle tissue. Electrospinning of the elastomer PLGA produced aligned fibres that had the correct topology to provide contact guidance for myoblast elongation and alignment. In addition, the electrospun scaffold required no surface modifications or incorporation of biologic material for adhesion, elongation, and differentiation of C2C12 murine myoblasts.
ISSN:1473-2262
1473-2262
DOI:10.22203/eCM.v019a19