Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases

Metabolic reprogramming contributes to the progression and prognosis of various kidney diseases. Glutamine is the most abundant free amino acid in the body and participates in more metabolic processes than other amino acids. Altered glutamine metabolism is a prominent feature in different kidney dis...

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Bibliographic Details
Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2024-07, Vol.17, p.2789-2807
Main Authors: Ou, Li-Ping, Liu, Yong-Jian, Qiu, Shi-Tong, Yang, Chen, Tang, Ji-Xin, Li, Xiao-Yu, Liu, Hua-Feng, Ye, Zhen-Nan
Format: Article
Language:English
Subjects:
B cells
Development and progression
Enzymes
Glutamine
glutaminolysis
Health aspects
Inflammation
Kidney diseases
Metabolites
Physiological aspects
Prognosis
therapeutic target
Citations: Items that this one cites
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Summary:Metabolic reprogramming contributes to the progression and prognosis of various kidney diseases. Glutamine is the most abundant free amino acid in the body and participates in more metabolic processes than other amino acids. Altered glutamine metabolism is a prominent feature in different kidney diseases. Glutaminolysis converts glutamine into the TCA cycle metabolite, alpha-ketoglutarate, via a cascade of enzymatic reactions. This metabolic pathway plays pivotal roles in inflammation, maladaptive repair, cell survival and proliferation, redox homeostasis, and immune regulation. Given the crucial role of glutaminolysis in bioenergetics and anaplerotic fluxes in kidney pathogenesis, studies on this cascade could provide a better understanding of kidney diseases, thus inspiring the development of potential methods for targeted therapy. Emerging evidence has shown that targeting glutaminolysis is a promising therapeutic strategy for ameliorating kidney disease. In this narrative review, equation including keywords related to glutamine, glutaminolysis and kidney are subjected to an exhaustive search on Pubmed database, we identified all relevant articles published before 1 April, 2024. Afterwards, we summarize the regulation of glutaminolysis in major kidney diseases and its underlying molecular mechanisms. Furthermore, we highlight therapeutic strategies targeting glutaminolysis and their potential clinical applications.
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S471711