Precision nephrotoxicity testing using 3D in vitro models

Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of...

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Bibliographic Details
Published in:Cell & bioscience 2023-12, Vol.13 (1), p.231-231, Article 231
Main Authors: Yu, Pengfei, Zhu, Hainan, Bosholm, Carol Christine, Beiner, Daniella, Duan, Zhongping, Shetty, Avinash K, Mou, Steve S, Kramer, Philip Adam, Barroso, Luis F, Liu, Hongbing, Cheng, Kun, Ihnat, Michael, Gorris, Matthew A, Aloi, Joseph A, Woldemichael, Jobira A, Bleyer, Anthony, Zhang, Yuanyuan
Format: Article
Language:English
Subjects:
3D culture model
Animal models
Biomarkers
Cell death
Drug development
Drug toxicity testing
Drugs
Fluid flow
Gene expression
Human primary renal cells
Kidneys
Laboratories
Mechanical stimuli
Microenvironments
Morphology
Nephrotoxicity
Pharmacovigilance
Physiology
Precision medicine
Stem cells
Toxicity
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Summary:Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-023-01187-0