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Precision nephrotoxicity testing using 3D in vitro models
Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of...
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| Published in: | Cell & bioscience 2023-12, Vol.13 (1), p.231-231, Article 231 |
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| creator | Yu, Pengfei Zhu, Hainan Bosholm, Carol Christine Beiner, Daniella Duan, Zhongping Shetty, Avinash K Mou, Steve S Kramer, Philip Adam Barroso, Luis F Liu, Hongbing Cheng, Kun Ihnat, Michael Gorris, Matthew A Aloi, Joseph A Woldemichael, Jobira A Bleyer, Anthony Zhang, Yuanyuan |
| description | Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety. |
| doi_str_mv | 10.1186/s13578-023-01187-0 |
| format | article |
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Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.</description><identifier>ISSN: 2045-3701</identifier><identifier>EISSN: 2045-3701</identifier><identifier>DOI: 10.1186/s13578-023-01187-0</identifier><identifier>PMID: 38129901</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>3D culture model ; Animal models ; Biomarkers ; Cell death ; Drug development ; Drug toxicity testing ; Drugs ; Fluid flow ; Gene expression ; Human primary renal cells ; Kidneys ; Laboratories ; Mechanical stimuli ; Microenvironments ; Morphology ; Nephrotoxicity ; Pharmacovigilance ; Physiology ; Precision medicine ; Stem cells ; Toxicity</subject><ispartof>Cell & bioscience, 2023-12, Vol.13 (1), p.231-231, Article 231</ispartof><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><rights>2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c493t-10e5f74132247127eac143b0d0345e6bfc4c1c803907a8cc956c22128dffb3103</cites><orcidid>0000-0002-5708-9718</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2914298325?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,36990,44566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38129901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Pengfei</creatorcontrib><creatorcontrib>Zhu, Hainan</creatorcontrib><creatorcontrib>Bosholm, Carol Christine</creatorcontrib><creatorcontrib>Beiner, Daniella</creatorcontrib><creatorcontrib>Duan, Zhongping</creatorcontrib><creatorcontrib>Shetty, Avinash K</creatorcontrib><creatorcontrib>Mou, Steve S</creatorcontrib><creatorcontrib>Kramer, Philip Adam</creatorcontrib><creatorcontrib>Barroso, Luis F</creatorcontrib><creatorcontrib>Liu, Hongbing</creatorcontrib><creatorcontrib>Cheng, Kun</creatorcontrib><creatorcontrib>Ihnat, Michael</creatorcontrib><creatorcontrib>Gorris, Matthew A</creatorcontrib><creatorcontrib>Aloi, Joseph A</creatorcontrib><creatorcontrib>Woldemichael, Jobira A</creatorcontrib><creatorcontrib>Bleyer, Anthony</creatorcontrib><creatorcontrib>Zhang, Yuanyuan</creatorcontrib><title>Precision nephrotoxicity testing using 3D in vitro models</title><title>Cell & bioscience</title><addtitle>Cell Biosci</addtitle><description>Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. 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In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.</description><subject>3D culture model</subject><subject>Animal models</subject><subject>Biomarkers</subject><subject>Cell death</subject><subject>Drug development</subject><subject>Drug toxicity testing</subject><subject>Drugs</subject><subject>Fluid flow</subject><subject>Gene expression</subject><subject>Human primary renal cells</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Mechanical stimuli</subject><subject>Microenvironments</subject><subject>Morphology</subject><subject>Nephrotoxicity</subject><subject>Pharmacovigilance</subject><subject>Physiology</subject><subject>Precision medicine</subject><subject>Stem cells</subject><subject>Toxicity</subject><issn>2045-3701</issn><issn>2045-3701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1rFDEUhoMottT-AS9kwBu9mJrvTC5La-tCQfHjOmQyJ2uWmcmaZKT992a7tbpiAkk4POcN7-FF6CXBZ4R08l0mTKiuxZS1uBZUi5-gY4q5aJnC5Olf7yN0mvMG18U1wUo8R0esI1RrTI6R_pTAhRzi3Myw_Z5iibfBhXLXFMglzOtmybuTXTZhbn6GkmIzxQHG_AI983bMcPpwn6BvV--_Xnxobz5ery7Ob1rHNSstwSC84oRRyhWhCqwjnPV4wIwLkL133BHXYaaxsp1zWkhHKaHd4H3PCGYnaLXXHaLdmG0Kk013Jtpg7gsxrY1NJbgRDJfO6mHwjHLMoQMN1SaTTPQ9l5z2VevNXmub4o-lGjRTyA7G0c4Ql2yoxkIQIZWs6Ot_0E1c0lydVopwqjtGxR9qbev_YfaxJOt2ouZcKamVVpRW6uw_VN0DTMHFGXyo9YOGtwcNlSlwW9Z2ydmsvnw-ZOmedSnmnMA_zohgs4uK2UfF1KiY-6iY3VBfPbhb-gmGx5bfwWC_AGV7s50</recordid><startdate>20231221</startdate><enddate>20231221</enddate><creator>Yu, Pengfei</creator><creator>Zhu, Hainan</creator><creator>Bosholm, Carol Christine</creator><creator>Beiner, Daniella</creator><creator>Duan, Zhongping</creator><creator>Shetty, Avinash K</creator><creator>Mou, Steve S</creator><creator>Kramer, Philip Adam</creator><creator>Barroso, Luis F</creator><creator>Liu, Hongbing</creator><creator>Cheng, Kun</creator><creator>Ihnat, Michael</creator><creator>Gorris, Matthew A</creator><creator>Aloi, Joseph A</creator><creator>Woldemichael, Jobira A</creator><creator>Bleyer, Anthony</creator><creator>Zhang, Yuanyuan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5708-9718</orcidid></search><sort><creationdate>20231221</creationdate><title>Precision nephrotoxicity testing using 3D in vitro models</title><author>Yu, Pengfei ; 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| subjects | 3D culture model Animal models Biomarkers Cell death Drug development Drug toxicity testing Drugs Fluid flow Gene expression Human primary renal cells Kidneys Laboratories Mechanical stimuli Microenvironments Morphology Nephrotoxicity Pharmacovigilance Physiology Precision medicine Stem cells Toxicity |
| title | Precision nephrotoxicity testing using 3D in vitro models |
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