Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine

In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data,...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2008-01, Vol.73 (8-9), p.815-824
Main Authors: Mitić Dragana M., Miodragović Đenana U., Sladić Dušan M., Vitnik Željko J., Miodragović Zoran M., Anđelković Katarina K., Radulović Milanka Đ., Juranić Nenad O.
Format: Article
Language:English
Subjects:
antimicrobial activity
dft
n-benzyloxycarbonyl-s-alanine
nmr
zn(ii) complexes
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Summary:In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC0809815M