DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis

C-reactive protein (CRP) and Serum amyloid A protein (SAA) increases with systemic inflammation and are related to worse survival for breast cancer survivors. This study examines the association between percent body fat and SAA and CRP and the potential interaction with NSAID use and weight change....

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Bibliographic Details
Published in:BMC cancer 2012-08, Vol.12 (1), p.343-343, Article 343
Main Authors: Dee, Anne, McKean-Cowdin, Roberta, Neuhouser, Marian L, Ulrich, Cornelia, Baumgartner, Richard N, McTiernan, Anne, Baumgartner, Kathy, Alfano, Catherine M, Ballard-Barbash, Rachel, Bernstein, Leslie
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Acute phase proteins
Acute-Phase Proteins - analysis
Adipose Tissue - physiology
Adipose tissues
Adult
Aged
Analysis
Body fat
Body mass index
Body weight
Breast cancer
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
Cancer survivors
Cross-Sectional Studies
Epidemiology
Family medical history
Female
Health aspects
Health care
Health sciences
Health services
Hispanic people
Humans
Inflammation
Lifestyles
Linear Models
Measurement
Medical research
Middle Aged
Obesity
Proteins
Public health
Surveys and Questionnaires
Survivors - statistics & numerical data
United States
Weight control
Womens health
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Summary:C-reactive protein (CRP) and Serum amyloid A protein (SAA) increases with systemic inflammation and are related to worse survival for breast cancer survivors. This study examines the association between percent body fat and SAA and CRP and the potential interaction with NSAID use and weight change. Participants included 134 non-Hispanic white and Hispanic breast cancer survivors from the Health, Eating, Activity, and Lifestyle Study. Body fat percentage, measured with Dual Energy X-ray Absorptiometer (DEXA), and circulating levels of CRP and SAA were obtained 30 months after breast cancer diagnosis. Circulating concentrations of CRP and SAA were associated with increased adiposity as measured by DEXA after adjustment for age at 24-months, race/ethnicity, dietary energy intake, weight change, and NSAID use. Survivors with higher body fat ≥35% had significantly higher concentrations of CRP (2.01 mg/l vs. 0.85 mg/l) and SAA (6.21 mg/l vs. 4.21 mg/l) compared to non-obese (body fat 
ISSN:1471-2407
1471-2407
DOI:10.1186/1471-2407-12-343