Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance

• Published in: International journal of endocrinology 2018-01, Vol.2018 (2018), p.1-16
• Main Authors: Li, Yu-xiu, Sun, Qi, Zhang, Huabing, Feng, Linbo, Cui, Xiangli, Zhu, Lixin, Li, Wei, Ping, Fan, He, Shuli, Zhou, Mei-cen, Zhao, Xuefeng
• Format: Article
• Language: English
• Subjects: Binding sites; Deoxyribonucleic acid; Diabetes; Diabetic retinopathy; Disease; DNA; Endocrinology; Genetic testing; Genomes; Genotype & phenotype; Glucose; Insulin resistance; Ligands; Lipids; Metabolism; Obesity; Polymorphism; Population; Proteins; Tumor necrosis factor-TNF
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2018/4636783

Objective. To investigate the association of polymorphisms in uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor (PPARγ) with glucolipid metabolism in Chinese Han population. Methods. Five hundred eighty-nine subjects were divided into normal glucose tolerance (NGT) group (n=198) and abnormal glucose tolerance group (n=358). HbA1c, blood lipid profile, plasma glucose, and insulin were determined. Insulin sensitivity (HOMA-IR and Matsuda index (ISIM)) and insulin secretion indexes (HOMA-β, early and total phase disposition index) were evaluated. Eight potential functional SNPs in UCP2 and 7 in PPARγ were selected. SNPs were genotyped on Sequenom MassARRAY platform. Results. The GG genotype of rs2920502 in PPARγ was associated with decreased risk of impaired glucose tolerance (G allele: OR: 0.818, 95%CI: 0.526–0.969, P=0.042; GG: OR: 0.715, 95%CI: 0.527–0.97, P=0.031). The TT genotype of rs3856806 in PPARγ was associated with increased risk of impaired glucose tolerance (T allele: OR: 1.46, 95%CI: 1.055–2.017, P=0.022; TT: OR: 1.58, 95%CI: 1.104–2.761, P=0.032). The GG genotype of rs2920502 in PPARγ had better blood glucose and increased insulin secretion and had lower HOMA-IR than GC/CC genotypes. Conclusion. It probably could prevent insulin resistance in early stage by classifying the genotype of rs649446 and rs7109266 in UCP2. The GG genotype of rs2920502 in PPARγ had a decreased risk for diabetes. The TT genotype of rs3856806 in PPARγ had an increased risk for diabetes.