Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review

: The search for new antimicrobial molecules is important to expand the range of available drugs, as well as to overcome the drug resistance of pathogens. One of the promising sources of antibacterial and antifungal metabolites is basidial fungi, which have wide biosynthetic capabilities. : The revi...

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Bibliographic Details
Published in:Antibiotics (Basel) 2024-10, Vol.13 (11), p.1026
Main Authors: Lysakova, Valeria, Krasnopolskaya, Larissa, Yarina, Maria, Ziangirova, Mayya
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics
Antifungal activity
Antifungal agents
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Bacteria
basidiomycetes
Basidiomycota
Chemical properties
culture liquid
Drug resistance
Ethanol
extracts
Fruit bodies
fruiting bodies
Fungi
Fungicides
Gram-negative bacteria
Gram-positive bacteria
Health aspects
Medical research
Metabolites
Microorganisms
Minimum inhibitory concentration
Multidrug resistant organisms
mycelium
Pathogens
Pharmaceutical research
Review
Staphylococcus infections
Strains (organisms)
Yeasts
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Summary:: The search for new antimicrobial molecules is important to expand the range of available drugs, as well as to overcome the drug resistance of pathogens. One of the promising sources of antibacterial and antifungal metabolites is basidial fungi, which have wide biosynthetic capabilities. : The review summarized the results of studying the antimicrobial activity of extracts and metabolites from basidiomycetes published from 2018-2023. : In all studies, testing for antibacterial and antifungal activity was carried out in in vitro experiments. To obtain the extracts, mainly the fruiting bodies of basidiomycetes, as well as their mycelia and culture liquid were used. Antimicrobial activity was found in aqueous, methanol, and ethanol extracts. Antimicrobial metabolites of basidiomycetes were isolated mainly from the submerged culture of basidiomycetes. Metabolites active against Gram-positive and Gram-negative bacteria and mycelial and yeast-like fungi were identified. : Basidiomycete extracts and metabolites have shown activity against collectible strains of bacteria and fungi and multi-resistant and clinical strains of pathogenic bacteria. The minimum inhibitory concentration (MIC) values of the most active metabolites ranged from 1 to 16.7 µg/mL.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics13111026