Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease

Conventional transcranial electrical stimulation (tES) is a non-invasive method to modulate brain activity and has been extensively used in the treatment of Parkinson's disease (PD). Despite promising prospects, the efficacy of conventional tES in PD treatment is highly variable across differen...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2022-04, Vol.14, p.880897-880897
Main Authors: Ni, Rui, Yuan, Ye, Yang, Li, Meng, Qiujian, Zhu, Ying, Zhong, Yiya, Cao, Zhenqian, Zhang, Shengzhao, Yao, Wenjun, Lv, Daping, Chen, Xin, Chen, Xianwen, Bu, Junjie
Format: Article
Language:English
Subjects:
Brain
Clinical trials
closed loop stimulation
Electrical stimuli
Electrodes
Movement disorders
Neurodegenerative diseases
neuromodulation
Neuroscience
non-invasive treatment
Parkinson's disease
Pathology
transcranial electrical stimulation (tES)
Transcranial magnetic stimulation
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Summary:Conventional transcranial electrical stimulation (tES) is a non-invasive method to modulate brain activity and has been extensively used in the treatment of Parkinson's disease (PD). Despite promising prospects, the efficacy of conventional tES in PD treatment is highly variable across different studies. Therefore, many have tried to optimize tES for an improved therapeutic efficacy by developing novel tES intervention strategies. Until now, these novel clinical interventions have not been discussed or reviewed in the context of PD therapy. In this review, we focused on the efficacy of these novel strategies in PD mitigation, classified them into three categories based on their distinct technical approach to circumvent conventional tES problems. The first category has novel stimulation modes to target different modulating mechanisms, expanding the rang of stimulation choices hence enabling the ability to modulate complex brain circuit or functional networks. The second category applies tES as a supplementary intervention for PD hence amplifies neurological or behavioral improvements. Lastly, the closed loop tES stimulation can provide self-adaptive individualized stimulation, which enables a more specialized intervention. In summary, these novel tES have validated potential in both alleviating PD symptoms and improving understanding of the pathophysiological mechanisms of PD. However, to assure wide clinical used of tES therapy for PD patients, further large-scale trials are required.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.880897