Targeting Lung-Gut Axis for Regulating Pollution Particle-Mediated Inflammation and Metabolic Disorders

Cigarette smoking (CS) or ambient particulate matter (PM) exposure is a risk factor for metabolic disorders, such as insulin resistance (IR), increased plasma triglycerides, hyperglycemia, and diabetes mellitus (DM); it can also cause gut microbiota dysbiosis. In smokers with metabolic disorders, CS...

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Published in:Cells (Basel, Switzerland) Switzerland), 2023-03, Vol.12 (6), p.901
Main Authors: Cheng, Tzu-Yu, Chang, Chih-Cheng, Luo, Ching-Shan, Chen, Kuan-Yuan, Yeh, Yun-Kai, Zheng, Jing-Quan, Wu, Sheng-Ming
Format: Article
Language:English
Subjects:
Air pollution
Cigarette smoke
Cigarette smoking
Diabetes Mellitus
Digestive system
Dysbacteriosis
Dysbiosis - microbiology
Environmental aspects
Fatty acids
Fatty Acids, Volatile
Fermentation
G protein-coupled receptors
Gastrointestinal tract
Health aspects
Histone deacetylase
Humans
Hyperglycemia
Inflammation
Inflammation - metabolism
Inflammatory bowel disease
Insulin
Insulin resistance
Intestinal microflora
Lung diseases
Lungs
lung–gut axis
Metabolic Diseases
metabolic disorder
Metabolic disorders
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Mortality
Particles
Particulate matter
Review
Risk factors
Triglycerides
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Summary:Cigarette smoking (CS) or ambient particulate matter (PM) exposure is a risk factor for metabolic disorders, such as insulin resistance (IR), increased plasma triglycerides, hyperglycemia, and diabetes mellitus (DM); it can also cause gut microbiota dysbiosis. In smokers with metabolic disorders, CS cessation decreases the risks of serious pulmonary events, inflammation, and metabolic disorder. This review included recent studies examining the mechanisms underlying the effects of CS and PM on gut microbiota dysbiosis and metabolic disorder development; one of the potential mechanisms is the disruption of the lung-gut axis, leading to gut microbiota dysbiosis, intestinal dysfunction, systemic inflammation, and metabolic disease. Short-chain fatty acids (SCFAs) are the primary metabolites of gut bacteria, which are derived from the fermentation of dietary fibers. They activate G-protein-coupled receptor (GPCR) signaling, suppress histone deacetylase (HDAC) activity, and inhibit inflammation, facilitating the maintenance of gut health and biofunction. The aforementioned gut microbiota dysbiosis reduces SCFA levels. Treatment targeting SCFA/GPCR signaling may alleviate air pollution-associated inflammation and metabolic disorders, which involve lung-gut axis disruption.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12060901