One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

A novel series of (1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between -hydrazonoyl chloride and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis....

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-11, Vol.21 (11), p.1532-1532
Main Authors: Gomha, Sobhi M, Kheder, Nabila A, Abdelhamid, Abdou O, Mabkhot, Yahia N
Format: Article
Language:English
Subjects:
Analgesics
anticancer activity
Anticonvulsants
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Asthma
bis(1,3,4-thiadiazole)
bis-hydrazonoyl chlorides
Breast cancer
Cell Line, Tumor
Cell Proliferation - drug effects
Chemistry Techniques, Synthetic
Cytotoxicity
Cytotoxins - chemical synthesis
Cytotoxins - chemistry
Cytotoxins - pharmacology
dipolar cycloaddition reaction
Drugs
Humans
Inhibitory Concentration 50
Leukemia
Lymphoma
methyl arylidene dithiocarbamate
Molecular Structure
Multiple myeloma
Ovaries
Pharmaceuticals
Pharmacy
Sarcoma
Structure-Activity Relationship
Thiadiazoles - chemical synthesis
Thiadiazoles - chemistry
Thiadiazoles - pharmacology
Thyroid gland
Tumors
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Summary:A novel series of (1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between -hydrazonoyl chloride and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the -thiadiazole derivatives , , , and had higher antitumor activity than the standard drug Imatinib.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21111532